Immunological Aspects of Liver Disease

  • Howard C. Thomas
  • Peter A. Miescher
  • Hans J. Mueller-Eberhard

Table of contents

  1. Front Matter
    Pages I-VI
  2. Howard C. Thomas
    Pages 1-5
  3. Ian R. Mackay, Senga Whittingham, John D. Mathews, Brian D. Tait
    Pages 7-18
  4. K. H. Meyer zum Büschenfelde, T. H. Hütteroth, M. Manns, B. Möller
    Pages 19-37
  5. Ralph Wright
    Pages 53-60
  6. Peter A. Berg, Harold Baum
    Pages 77-95
  7. H. C. Thomas, O. Epstein
    Pages 97-106
  8. Roy Calne
    Pages 107-115
  9. Leonardo Bianchi
    Pages 141-158
  10. Gary A. Levy, Francis V. Chisari
    Pages 159-179
  11. Back Matter
    Pages 207-210

About this book


Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to "self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu­ lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .


Antigen autoimmune disease cancer diseases hepatitis hepatitis B immunology infection liver liver disease lymphocytes pathogenesis pathology transplantation virus

Editors and affiliations

  • Howard C. Thomas
    • 1
  • Peter A. Miescher
    • 2
  • Hans J. Mueller-Eberhard
    • 3
  1. 1.Academic Department of MedicineThe Royal Free Hospital and Medical SchoolHampstead, LondonGreat Britain
  2. 2.Division d’Hématologie du Department de Médicine Hôpital CantonalGenèveSwitzerland
  3. 3.Department of Molecular ImmunologyScripps Clinic and Research FoundationLa JollaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-11310-2
  • Online ISBN 978-3-642-68446-3
  • Buy this book on publisher's site