Spinal Opiate Analgesia

Experimental and Clinical Studies

  • Tony L. Yaksh
  • Hermann Müller

Table of contents

  1. Front Matter
    Pages I-XII
  2. H. Müller, U. Börner, M. Stoyanov, G. Hempelmann
    Pages 9-17
  3. K. Hanaoka, M. Tagami, H. Toyooka, H. Yamamura
    Pages 24-29
  4. T. A. Torda, D. A. Pybus, H. Liberman, M. Clark, M. Crawford
    Pages 30-32
  5. U. Börner, H. Müller, M. Stoyanov, G. Hempelmann
    Pages 33-36
  6. H. J. Birkhan, B. Rosenberg, K. Simon, B. Moskowitz
    Pages 37-39
  7. G. P. Handjis, A. Liolios, A. Anagnostakos, G. Vailas, C. E. Tsantakis
    Pages 47-50
  8. B. Ch. Jørgensen, H. B. Andersen, A. Engquist
    Pages 51-52
  9. Y. Kawashima, N. Uchida, S. Kawahira, K. Meguro, T. Nampo, Y. Fujita
    Pages 53-57
  10. A. Muller, A. Straja, J. P. Dupeyron, D. Franckhauser, E. Dumeny
    Pages 62-66
  11. H. Müller, U. Börner, M. Stoyanov, G. Hempelmann
    Pages 67-85
  12. M. Rondomanska, J. de Castro, L. Lecron
    Pages 91-94
  13. J. Seebacher, M. Henry, C. Leveque, Y. Darbois, P. Viars
    Pages 95-98
  14. M. Zenz, S. Piepenbrock, G. Otten, M. Hüsch
    Pages 109-113
  15. B. Kossmann, A. Driessen, H. H. Mehrkens, W. Dick
    Pages 114-115
  16. B. Kossmann, A. Driessen, H. H. Mehrkens, W. Dick
    Pages 116-120
  17. H. Müller, M. Stoyanov, U. Börner, G. Hempelmann
    Pages 125-137
  18. A. Tung, R. Tenicela, G. Barr, P. Winter
    Pages 138-140
  19. M. Zenz, S. Piepenbrock, J. Hilfrich, M. Hüsch
    Pages 141-144
  20. Back Matter
    Pages 145-150

About this book


The recent development of the use of spinal opiates as a rational therapy for pain rests on clear and certain experimental data. We have long known the spinal cord to be a highly complex structure. Anatomical studies of the substantia gelatinosa have repeatedly demonstrated signs of massive synaptic interaction between primary afferents, descending pathways and intrinsic neurons. Yet, to date that knowledge, insofar as clinical therapy is concerned, has permitted us only to destroy certain connections within the spinal cord in the hopes that the substrate mediating pain could be anatomically differentiated from those which mediate other function. Though cordotomies are clearly effective under certain circumstances, they suffer from the fact the spinal cord is not organized in such an anatomically discrete fashion as is often times drawn in basic medical text. Rather, functions intertwine exquisitely and specific physical interventions are no more likely to produce a specific effect than smashing of the fmgertip with a hammer will produce just a loss of the fingernail. The development of specific therapies of the spinal cord has come about by our growing aware­ ness of the intricate organization of the pharmacological substrates associated with specific neural function.


Analgesia Anästhesie Opiat Opiate Spinalanästhesie complications pain surgery

Editors and affiliations

  • Tony L. Yaksh
    • 1
  • Hermann Müller
    • 2
  1. 1.Depts. of Neurologic Surgery and PharmacologyMayo FoundationRochesterUSA
  2. 2.Dept. of Anesthesiology and Intensive Care MedicineJustus Liebig UniversityGiessenFederal Republic of Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-11036-1
  • Online ISBN 978-3-642-68261-2
  • Series Print ISSN 0171-1814
  • Buy this book on publisher's site