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Nitrates III

Cardiovascular Effects

  • P. R. Lichtlen
  • H.-J. Engel
  • A. Schrey
  • H. J. C. Swan
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XXI
  2. Basic Action of Nitrates

    1. Front Matter
      Pages 1-1
    2. M. G. Bogaert, M. T. Rosseel, O. Teirlynck
      Pages 23-26
    3. J. O. Parker, U. Thadani
      Pages 27-36
    4. P. R. Lichtlen, H.-J. Engel, A. Schrey, H. J. C. Swan
      Pages 37-38
  3. Pharmacodynamics and Kinetics

    1. Front Matter
      Pages 39-39
    2. T. Taylor, L. F. Chasseaud
      Pages 40-46
    3. L. F. Chasseaud, T. Taylor
      Pages 47-53
    4. W. Rudolph, R. Blasini, K.-L. Froer, U. Bruegmann, A. Mannes, D. Hall
      Pages 75-81
    5. A. Distante, A. L’Abbate, C. Palombo, C. Michelassi, D. Rovai, M. A. Morales et al.
      Pages 82-90
    6. B. Pitt, H. Colfer, A. Keith, P. Stetson, J. Walton, J. Brymer et al.
      Pages 91-94
    7. W. H. Down, L. F. Chasseaud, S. A. Ballard
      Pages 110-116
    8. P. R. Lichtlen, H.-J. Engel, A. Schrey, H. J. C. Swan
      Pages 123-124
  4. Hemodynamics

    1. Front Matter
      Pages 125-125
    2. I. Amende, R. Simon, W. P. Hood Jr., W. Daniel, P. Lichtlen
      Pages 126-133
    3. C. R. Conti, L. G. Christie Jr., W. W. Nichols, R. L. Feldman, C. J. Pepine, J. Mehta
      Pages 151-156
    4. W. Doering, H. Hacker, W. Reiser, E. König
      Pages 175-179
    5. P. R. Lichtlen, H.-J. Engel, A. Schrey, H. J. C. Swan
      Pages 180-181
  5. Coronary Flow, Perfusion

  6. Vascular Effects

    1. Front Matter
      Pages 223-223
    2. A. L’Abbate, O. Parodi, I. Simonetti, Maria Giovanna Trivella, M. Baroni, G. Valli
      Pages 224-230
    3. W. Rafflenbeul, F. Urthaler, R. O. Russell, T. N. James, P. R. Lichtlen
      Pages 231-237
    4. G. Sauer, H.-H. Wille, U. Tebbe, K.-L. Neuhaus, H. Kreuzer
      Pages 251-255
    5. V. Hossmann, H. Wegener, B. Wegener, F. Saborowski, K. Cäsar
      Pages 263-270
    6. P. R. Lichtlen, H.-J. Engel, A. Schrey, H. J. C. Swan
      Pages 277-278
  7. Pulmonary Circulation

    1. Front Matter
      Pages 279-279
    2. G. Kober, R. Grossmann, W. Schulz, M. Kaltenbach
      Pages 280-284

About these proceedings

Introduction

Pharmacological and clinical research on nitrates continues to be of growing interest in many centers. This is surprising in view of the fact that their favorable effects in angina pectoris were described by Brunton and by Murrell in the Lancet more than 100 years ago. As expected, a host of new information has been collected since the two previous symposia on nitrates held in Stockholm in 1975 and Berlin in 1978. New insights were gained into the pharmacology, pharmacokinetics and pharmacodynamics of nitrates, as well as into their clinical effects in acute and chronic ischemic heart diseases and in severe congestive heart failure. Relatively little progress, however, was observed in research into the basic action of nitrates. Although most investigators agree that intracellular sequestration of calcium is probably the main mechanism by which nitrates lead to the reduction of vascular smooth muscle tone, the exact site of their action still remains undefined. In contrast, dose-dependent differences in venous and arteriolar tone have long been clearly established. Treatment was again in the main stream of discussion. The question of tolerance following long-term administration was discussed in depth and the term "pseudotolerance" was introduced to describe the adaptation of the body's circulatory system to chronic vasodilation. This is especially important in long term prophylactic antiischemic treatment in stable, as well as in unstable angina pectoris (i.e. during increased vasomotor tone - spasm).

Keywords

Herz-Kreislauf-System Nitrat Nitrates angina pectoris calcium circulation clinical research heart kinetics lead pharmacodynamics pharmacokinetics research

Editors and affiliations

  • P. R. Lichtlen
    • 1
  • H.-J. Engel
    • 2
  • A. Schrey
    • 3
  • H. J. C. Swan
    • 4
  1. 1.Abteilung für KardiologieMed. Hochschule HannoverHannover 61Germany
  2. 2.Zentralkrankenhaus „Links der Weser“Bremen 61Germany
  3. 3.Pharma-Schwarz GmbHMonheimGermany
  4. 4.Dept. of CardiologyCedars-Sinai Medical CenterLos AngelesUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68085-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68087-8
  • Online ISBN 978-3-642-68085-4
  • Buy this book on publisher's site