Mechanism of Toxic Action on Some Target Organs

Drugs and Other Substances Proceedings of the European Society of Toxicology Meeting held in Berlin (West), June 25—28, 1978

  • Philip L. Chambers
  • Peter Günzel
Conference proceedings

Part of the Archives of Toxicology book series (TOXICOLOGY, volume 2)

Table of contents

  1. Front Matter
    Pages I-X
  2. Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity

  3. The Influence of the Neuro-Endocrine System on the Toxic Reactions Due to Hormones and Other Compounds

  4. Induction of Adaptive and Malignant Liver Growth by Drugs and Environmental Pollutants

  5. Organotropy as a Toxicological Phenomenon

  6. TCDD — Seveso

    1. Front Matter
      Pages 289-289
  7. Free Communications and Poster Sessions

    1. Front Matter
      Pages 303-303
    2. G. Hennighausen, P. Lange
      Pages 315-320
    3. A. Jacqueson, M. Thevenin, J.-M. Warnet, J.-R. Claude, R. Truhaut
      Pages 327-331
    4. E. Elovaara, H. Savolainen, P. Pfäffli, H. Vainio
      Pages 345-348
    5. G. M. Scoto, C. Spadaro, S. Spampinato, N. Nossan, R. Arrigo-Reina, S. Ferri
      Pages 375-380

About these proceedings


The first oral contraceptive became available in 1960 and since then these sub­ stances, which have been used by millions of women, have probably been the most widely studied group of drugs in medical history (Drill, 1966, 1977). Part of the evaluation oCoral contraceptives has involved their effect on the reproductive organs of women, with particular attention directed to evaluation of a possible carcinogenic effect of these steroids. To the extent that cancer of the reproductive organs is a common finding in women, the endogenous female sex hormones have been implicated in the occur­ rence of the cancer. The administration of estrogen has also been reported to in­ crease the incidence of cancer of the breast, cervix or endometrium in some strains or species of animals. Thus, because of the possible tumorigenic effect of estrogens there has been considerable interest in the relationship of oral contraceptives to cancer of the breast and genital tract.


Drogen Thymus amphetamine assessment cancer cell dopamine environment ethanol pathology pharmacokinetics pollutants steroids toxicology xenobiotic

Editors and affiliations

  • Philip L. Chambers
    • 1
  • Peter Günzel
    • 2
  1. 1.Dept. of PharmacologyTrinity CollegeDublin 2Ireland
  2. 2.Dept. of Exp. ToxicologySchering AGBerlin-BergkamenGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-09305-3
  • Online ISBN 978-3-642-67265-1
  • Series Print ISSN 0171-9750
  • Buy this book on publisher's site