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Immunodiagnosis and Immunotherapy of Malignant Tumors

Relevance to Surgery

  • Hans-Dieter Flad
  • Christian Herfarth
  • Michael Betzler
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-XII
  2. Pathophysiologic Aspects of Tumor Development

    1. Front Matter
      Pages 1-1
    2. T. M. Fliedner
      Pages 3-10
    3. H. O. Sjögren
      Pages 20-28
    4. J. Kusche, C. D. Stahlknecht
      Pages 29-30
  3. Clinical Significance of Immunologic Tests for Tumor Diagnosis

    1. Front Matter
      Pages 31-31
    2. Tumor-Associated Antigens

      1. B. Heymer, A. Quentmeier, G. Horn, O. Haferkamp
        Pages 50-55
      2. K. Havemann, C. Gropp, F.-G. Lehmann, P. Preisser, S. von Kleist
        Pages 56-64
      3. R. J. Ablin, R. A. Bhatti, P. D. Guinan
        Pages 65-80
      4. M. Micksche, C. Cerni, P. Fischer, M. Vetterlein
        Pages 91-92
    3. Cell-Mediated Immune Reactions

      1. L. E. Hughes, C. Teasdale, J. F. Forbes, J. W. Hillyard, R. H. Whitehead
        Pages 95-102
      2. H. J. Wanebo, C. M. Pinsky, E. J. Beattie, H. F. Oettgen
        Pages 103-114
      3. R. H. Whitehead, L. E. Hughes, H. S. Shukla
        Pages 115-121
      4. H. H. Peter, I. Korn-Nitschmann, F. Krapf, H. C. Siewertsen, P. Schmidt, W. Leibold
        Pages 129-142
      5. N. Thatcher, R. Swindell, M. K. Palmer, D. Crowther
        Pages 153-163
      6. A. J. Cochran, L. J. Ogg, R. M. Mackie, A. M. Jackson, G. Todd
        Pages 164-168
      7. R. H. Whitehead
        Pages 184-185
      8. U. Nitzschke, Th. Zwergel, F. Lampert
        Pages 186-188
  4. Immunotherapeutic Approaches

  5. Special Procedures in Cancer Therapy — Effects on the Immune Status

    1. Front Matter
      Pages 245-245
    2. H. A. Fabricius, H. Neumann, R. Engelhardt, G. W. Löhr, R. Stahn
      Pages 281-281
    3. R. J. Ablin, P. D. Guinan
      Pages 282-304
    4. S. Langer, K. Schweizer, H. P. Bräcker, U. Freisburger
      Pages 305-310
    5. W. Fekl
      Pages 315-316
  6. Summing Up

    1. Front Matter
      Pages 317-317
    2. K. Rother, H.-D. Fad, Ch. Herfarth
      Pages 319-325
  7. Back Matter
    Pages 326-332

About these proceedings

Introduction

The concept of immunologic responses against tumors is currently under intense scrutiny throughout the world. The evidence for the existence of tumor-specific transplantation antigens (TSTA) and specific immune reactions to them in experimental animals is overwhelming. The available data concerning human tumors are controversial. The reason for this is partially that antigens detectable on human tumors by in vitro assays have not been biologically characterized. In other words, we do not know if the antigens on human tumors are acting as the targets for immunologically mediated rejection processes in vivo. It was the purpose of this workshop to bring experimental tumor immunologists and clinical oncologists together in order to disclose facts and limits in tumor immunology. Clinicians were to learn how shaky the ground becomes once the experimentalist looks beyond the edge of the mouse cage. Tumor biologists heard the clinicians' urgent cry for controlled randomized trials of immunotherapy which thus reflects clearly that immunotherapy in its present form without knowledge of dose-effect-relationship does not work. Nobody would deny that the problem of human cancer smells of immunology, but since we are just about to taste it the essential ingredient might be different. In other words one might look at present rather at immunological epiphenomena than at mechanisms of tumor immul1lty operating in vivo. This problem was among others a central issue of this workshop.

Keywords

antigen breast cancer cancer cancer therapy diagnosis diseases growth immunology immunotherapy neoplasm oncology surgery therapy transplantation tumor

Editors and affiliations

  • Hans-Dieter Flad
    • 1
  • Christian Herfarth
    • 2
  • Michael Betzler
    • 2
  1. 1.Abteilung Mikrobiologie, Laborbereich ImmunologieUniversität UlmUlmGermany
  2. 2.Allgemeine ChirurgieUniversität UlmUlmGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-67166-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-09161-5
  • Online ISBN 978-3-642-67166-1
  • Buy this book on publisher's site