© 1978


  • John R. Vane
  • Sergio H. Ferreira

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 50 / 1)

Table of contents

  1. Front Matter
    Pages I-XXVII
  2. Historical Survey of Definitions and Concepts of Inflammation

  3. The Inflammatory Reaction

    1. Front Matter
      Pages 5-5
    2. M. Rochae E Silva
      Pages 6-25
    3. J. V. Hurley
      Pages 26-67
    4. R. van Furth
      Pages 68-108
    5. L. E. Glynn
      Pages 206-230
    6. J. L. Turk, D. A. Willoughby
      Pages 231-266
    7. R. B. Zurier, K. Krakauer
      Pages 295-313
    8. J. Morley
      Pages 314-342
  4. Inflammatory Mediators Released From Cells

    1. Front Matter
      Pages 343-343
    2. R. J. Flower
      Pages 374-422
  5. Inflammatory Mediators Generated by Activation of Plasma Systems

    1. Front Matter
      Pages 423-423
    2. A. Nicholson, D. T. Fearon, K. F. Austen
      Pages 425-463
    3. J. Garcia Leme
      Pages 464-522

About this book


Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti­ inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti­ Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication.


Chemokine Histamin Hypothalamus Insulin Nicotin Prostaglandin antibody antigen asthma biochemistry bronchial asthma chemistry inflammation neurotransmitter pharmacology

Editors and affiliations

  • John R. Vane
    • 1
  • Sergio H. Ferreira
    • 2
  1. 1.The Wellcome Research LaboratoriesBeckenham, KentUK
  2. 2.Faculdade de Medicina de Ribeirão PretoUniversidade de São PauloSão PauloBrazil

Bibliographic information

  • Book Title Inflammation
  • Series Title Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1978
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-08639-0
  • Softcover ISBN 978-3-642-66890-6
  • eBook ISBN 978-3-642-66888-3
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XXVIII, 786
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacy
  • Buy this book on publisher's site