© 1978

Histamine II and Anti-Histaminics

Chemistry, Metabolism and Physiological and Pharmacological Actions

  • Mauricio Rocha e Silva

Table of contents

  1. Front Matter
    Pages II-XIX
  2. Recent Developments of the Histamine Problem

    1. B. Mauricio Altura, S. Halevy, L. R. Johnson
      Pages 1-56
    2. A. Goth, B. Uvnäs, N. Chakravarty
      Pages 57-108
    3. R. W. Schayer, H. Wetterqvist, Mauricio A. Beaven, Z. Horakova
      Pages 109-173
  3. Chemistry and Structure-Activity Relationships of Synthetic Anti-Histaminics

  4. Mechanism of Action of Antihistaminics

    1. Mauricio Rocha e Silva
      Pages 295-332
    2. Frans G. Van Den Brink, Eric J. Lien
      Pages 333-367
  5. Pharmacological Actions of Antihistaminics

    1. Mauricio Rocha e Silva, Abilio Antonio
      Pages 381-437
    2. C. G. Van Arman
      Pages 505-512
  6. Absorption, Distribution, Metabolism, and Elimination of Antihistamines

  7. Therapeutic Action of Anti-Histaminics

  8. Back Matter
    Pages 603-702

About this book


In the preface to Part I of this volume, which appeared in 1966, we stated: " ... we had to leave the Antihistaminics for another volume of unpredictable dimensions. In 1924, eight pages inserted in a Chapter on Mutterkorn by Arthur R.Cushing were considered enough, in Vol. II, Part II, pp. 1319-1326 of the Hand­ buch. Now 922 pages did not suffice to cover all aspects of the subject ... the subject has been expanded in so many directions, that the anti histaminic part had to be excluded from the present volume. Possibly, another thousand pages will be necessary to cover what remains of the subject."* This prediction was fulfilled, and the subject of histamine has grown to such an extent that dealing with the antihistaminics only in Part II would be quite inadequate. It is imperative to include the large number of recent findings on the subject of histamine, namely the splitting of its pharmacologic receptors, and the great variety of new contributions on ,its participation in physiopathologic phenomena, metabolism and interaction with newly found mediators.


Antihistaminikum Histamin chemistry metabolism research

Editors and affiliations

  • Mauricio Rocha e Silva
    • 1
  1. 1.Department of Pharmacology, Faculty of Medicine of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

Bibliographic information

  • Book Title Histamine II and Anti-Histaminics
  • Book Subtitle Chemistry, Metabolism and Physiological and Pharmacological Actions
  • Authors M. Rocha e Silva
  • Series Title Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology
  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1978
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-3-540-07849-4
  • Softcover ISBN 978-3-642-66447-2
  • eBook ISBN 978-3-642-66445-8
  • Series ISSN 0171-2004
  • Series E-ISSN 1865-0325
  • Edition Number 1
  • Number of Pages XX, 702
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Medicine/Public Health, general
  • Buy this book on publisher's site