Teratology

Trends and Applications

  • C. L. Berry
  • D. E. Poswillo

Table of contents

  1. Front Matter
    Pages I-X
  2. New Attitudes to Experimental Teratology

    1. Front Matter
      Pages 1-1
    2. M. C. Johnston, R. M. Pratt
      Pages 2-16
    3. K. S. Brown
      Pages 34-48
    4. T. A. Connors
      Pages 49-79
  3. Problems of Predictive Teratology

    1. Front Matter
      Pages 81-81
    2. C. L. Berry, J. P. Germain
      Pages 83-102
    3. S. M. Barlow, F. M. Sullivan
      Pages 103-120
    4. Back Matter
      Pages 82-82
  4. Influencing the Fetal Milieu

    1. Front Matter
      Pages 147-147
    2. K. Benirschke
      Pages 148-164
    3. D. Sopher
      Pages 165-179
  5. New Aspects of Developmental Teratology

  6. Back Matter
    Pages 235-240

About this book

Introduction

In the fifteen years since the thalidomide disaster teratology has become a science in its own right, distinct from its progenitors, experimental embryology and develop­ mental biology, but bearing many of the familiar features of both parents. In this growth period there have been contributions from many different scientific disciplines as diverse as molecular biology and obstetrics, which have united in the field of study of congenital malformations. Scientists in academic departments, government research institutes and industrial pharmacology have all explored ways of evaluating the potential of drugs and chem­ icals to damage the embryo; strict methods of screening for teratogenicity have be­ come mandatory in most parts of the world. Despite a wealth of basic information in the fields of genetics and embryology, there is little concrete knowledge of the causal mechanisms of malformation in Man, and even less concerning the relevance to Man of those laboratory and animal tests which decide the fate of potentially useful drugs. It is timely, therefore, that in 1975 a group of young and active sci­ entists and clinicians concerned with the broader implications of teratology should review the past and look to the future of this emerging speciality. In this volume the editors have blended the opinions of teratologists; their message presages change in many of the old and accepted areas of investigative teratology.

Keywords

Laboratory biology chromosome drugs embryo embryology fat genes genetics growth molecular biology obstetrics pharmacology research screening

Editors and affiliations

  • C. L. Berry
    • 1
    • 2
  • D. E. Poswillo
    • 3
    • 4
  1. 1.Guy’s Hospital Medical SchoolLondonEngland
  2. 2.Guy’s HospitalLondonEngland
  3. 3.Royal College of Surgeons of EnglandLondonEngland
  4. 4.Queen Victoria HospitalEast GrinsteadEngland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-66172-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1975
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-66174-7
  • Online ISBN 978-3-642-66172-3
  • About this book