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Unclassifiable Leukemias

  • Marcel Bessis
  • George Brecher
Conference proceedings

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Present Practice of Classification, its Utility and Limitations

    1. Front Matter
      Pages 1-1
    2. Jean Bernard
      Pages 3-5
    3. D. A. G. Galton, J. V. Dacie
      Pages 17-24
    4. G. Mathé, D. Belpomme, D. Dantchev, P. Pouillart, J. R. Schlumberger, M. Lafleur
      Pages 25-36
    5. G. Mathé, D. Belpomme, D. Dantchev, P. Pouillart, L. Navares, G. Hauss et al.
      Pages 37-52
    6. Marcel Bessis, George Brecher
      Pages 53-56
    7. Marcel Bessis, George Brecher
      Pages 57-60
  3. New Techniques Used in Cytological Diagnosis

    1. Front Matter
      Pages 61-61
    2. Marcel Bessis, George Brecher
      Pages 67-70
    3. Bo Thorell
      Pages 71-77
    4. Marcel Bessis, George Brecher
      Pages 79-80
    5. Marcel Bessis, George Brecher
      Pages 91-94
    6. J. L. Binet, G. Dighiero, P. D’Athis, M. Feinermann, F. de Montaut, J. Seroude
      Pages 95-97
    7. Marcel Bessis, George Brecher
      Pages 99-99
    8. John M. Bennett, Carolyn E. Reed
      Pages 101-108
    9. Marcel Bessis, George Brecher
      Pages 109-113
    10. D. Catovsky, B. Frisch, Susan Van Noorden
      Pages 115-124
    11. Marcel Bessis, George Brecher
      Pages 125-127
    12. Marcel Bessis, George Brecher
      Pages 137-138
    13. Marcel Bessis, George Brecher
      Pages 147-147
    14. Marcel Bessis, George Brecher
      Pages 159-160
    15. Marcel Bessis, George Brecher
      Pages 171-172
    16. José M. Trujillo, Michael J. Ahearn, Ann Cork
      Pages 173-175
    17. Marcel Bessis, George Brecher
      Pages 177-179
  4. Pathophysiology of the Leukemic Cells

    1. Front Matter
      Pages 181-181
    2. Marcel Bessis, George Brecher
      Pages 189-190
    3. D. Catovsky, A. V. Hoffbrand, N. B. Ikoku, Aviva Petrie, D. A. G. Galton
      Pages 201-211
    4. Marcel Bessis, George Brecher
      Pages 213-215
    5. Marcel Bessis, George Brecher
      Pages 223-225
    6. Marcel Bessis, George Brecher
      Pages 235-237
    7. P. Stryckmans, L. Debusscher, T. Peltzer, M. Socquet
      Pages 239-248
    8. Marcel Bessis, George Brecher
      Pages 249-251
  5. Summary and Discussion

    1. Front Matter
      Pages 253-253
    2. Jean Bernard
      Pages 255-256
    3. George Brecher
      Pages 257-258
    4. Howard C. Mel
      Pages 259-262
  6. General Discussion

    1. Marcel Bessis, George Brecher
      Pages 263-267

About these proceedings

Introduction

Jean BERNARD * I should like to begin with an assumption and a paradox. The assumption is that leukemia is a disease of a stem cell characterized by pathologie alterations of that cell and its progeny. All present research and discussions are centered around the leukemic cell. So is this symposium, which would not take place except for our primary interest in the leukemic cell. This does not preclude, of course, consideration of other definitions and other approaches to the prOblem. By definition, then, the leukemic cells are abnormal cells and their metabolism and functions are presumed to be abnormal. Yet, the classification of the different types of leukemias is based upon the characteristics of normal cells. We talk of "lymphoblasts" and "myeloblasts" as predominant cell types in leukemia. This leads to a double paradox. In the first pi ace it is clearly illogical to classify abnormal cells by their resemblance to normal cells, since their very abnormality consists in not being normal. Yet, as a second paradox, the classifica­ ti on has had the happy consequence of ai ding us in the treatment and prognosis of leukemia for the past 25 years. A more detailed analysis shows that the consequence of this paradox are complex: while there exists a useful correlation between cellular types, treatment and prognosis, numerous problems and difficulties persist. The most serious of them concems the "unclassified leukemias" which are the reason for this reunion.

Keywords

Leukemias anemia blood cell chemistry classification diagnosis leukemia metabolism pathology physiology stem cell

Editors and affiliations

  • Marcel Bessis
    • 1
  • George Brecher
    • 2
  1. 1.Institut de Pathologie CellulaireHôpital de BicêtreKremlin-BicêtreFrance
  2. 2.School of Medicine Department of Clinical Pathology and Laboratory MedicineUniversity of CaliforniaSan FranciscoUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-66126-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1975
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-07242-3
  • Online ISBN 978-3-642-66126-6
  • Buy this book on publisher's site