Latest Advances with Special Reference to Gastric and Duodenal Ulcers Disease

  • Fritz Holle
  • Sven Andersson

Table of contents

  1. Front Matter
    Pages I-XII
  2. Historical Outline

    1. F. Holle
      Pages 1-5
  3. Anatomy

  4. Histopathology

    1. W. Creutzfeldt, C. Creutzfeldt, R. Arnold
      Pages 19-23
  5. Physiology and Pathophysiology of the Vagus and Gastro-intestinal Hormones

  6. Experimental Research on the Effects of SPV on Gastric Secretion and Motility in Animal and Man

    1. F. Holle, H. Bauer, H. D. Becker, D. D. Reeder, J. C. Thompson
      Pages 77-86
    2. M. Kuramoto, T. Kawahigashi, Y. Sakakihara, S. Takita
      Pages 94-98
    3. Yukio Sakakihara, Toshiaki Kushida, Nobushige Katto, Shuhei Takita
      Pages 99-102
    4. Kinichi Nakamura, Kazuyoshi Ishi, Mitsuo Kusano, Shiro Hayashi, W. Hartel, P. Alken et al.
      Pages 109-112
    5. Pai-Ching Sheen, Fumio Nakayama, Masaya Nishimura
      Pages 113-115
    6. F. Holle
      Pages 116-117
    7. G. Feifel
      Pages 122-123
  7. Clinic of SP-Vagotomy

  8. Clinical Results

    1. Lloyd M. Nyhus
      Pages 193-196
    2. F. Holle, H. Bauer
      Pages 198-205
    3. Fritz Holle, Sven Andersson
      Pages 206-219
    4. Fritz Holle, Sven Andersson
      Pages 220-221
    5. Fritz Holle, Sven Andersson
      Pages 222-223
    6. Fritz Holle, Sven Andersson
      Pages 224-226
    7. F. Holle
      Pages 227-232
  9. Back Matter
    Pages 233-244

About this book


This monograph is a summary of observations collected over the past ten years on vagal denervation of the stomach and the functional pathology of the vagotomized stomach. It is primarily a continuation of the work we (Holle and Heinrich, 1954) began with fundectomy - the prototype of proximal dener­ vation of the stomach. This was the starting point for the develop­ ment of selective proximal vagotomy (SPV). Between 1961 and 1964 the SPY technique was developed to the extent that it could be applied clinically from January 1,1964. Like most clinical innovations, the development took place in several stages. A report on the first 235 surgical cases (1961-1967) appeared in 1968 in F. Holle's Special Surgery of the Stomach, pp. 508-509, and in 1969 in Surgery of the Stomach and Duodenum by Harkins and Nyhus, 2nd edition, pp. 629-634. Since that time it has been possible to demonstrate on the basis of 1200 operated cases as well as animal experiments that the new technique we introduced represents a successful, nonresecting surgical treatment of gastric and duodenal ulcers. It is important to have a long series of clinical cases from the same source, because it is not until a large number of individual observations have been collected concern­ ing complications of diagnosis, indications and technique that is it possible to analyse the relationships between them.


Gastric Ulcers Disease Surgery Ulcers Vagotomie anatomy cell clinic diagnosis diagnostics histopathology nomenclature pathology physiology stress

Editors and affiliations

  • Fritz Holle
    • 1
  • Sven Andersson
    • 2
  1. 1.Chirurg. Poliklinik der Universität8 München 2Germany
  2. 2.Farmakoligska InstitutioneKarolinska InstitutetStockholm 60Sweden

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1974
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-06801-3
  • Online ISBN 978-3-642-65889-1
  • Buy this book on publisher's site