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Current Topics in Microbiology and Immunology

Ergebnisse der Mikrobiologie und Immunitätsforschung

  • W. Arber
  • W. Braun
  • R. Haas
  • W. Henle
  • P. H. Hofschneider
  • N. K. Jerne
  • P. Koldovský
  • H. Koprowski
  • O. Maaløe
  • R. Rott
  • H. G. Schweiger
  • M. Sela
  • L. Svruček
  • P. K. Vogt
  • E. Wecker

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 59)

Table of contents

  1. Front Matter
    Pages i-iii
  2. David W. Kingsbury
    Pages 1-33
  3. R. Drzeniek
    Pages 35-74
  4. Robert G. Webster
    Pages 75-105
  5. Thomas L. Benjamin
    Pages 107-133
  6. Georges Roelants
    Pages 135-165
  7. Edna Mozes, G. M. Shearer
    Pages 167-200
  8. Back Matter
    Pages 201-258

About these proceedings

Introduction

Influenza continues to be one of the major epidemic diseases of man and is, in fact, his only remaining pandemic disease (BEVERIDGE, 1969). This is largely because influenza virus undergoes extreme antigenic variation, the mechanism of which is still poorly understood. Two kinds of antigenic variation occur in influenza viruses, antigenic drift and major antigenic shifts; both involve chan­ ges in the hemagglutinin and neuraminidase antigens on the surface of the virus. Antigenic drift, which involves gradual changes in the surface antigens of influenza virus, is thought to result from the selection by an immune popula­ tion of mutant virus particles with altered antigenic determinants. These mutants therefore possess a growth advantage in the presence of antibody (FRAN­ CIS and MAASSAB, 1965; ARCHETTI and HORSFALL, 1950; HAMRE et aI., 1958). It has been shown that antigenic mutants isolated in vitro by selection with antibody have changes in amino acid sequence in the polypeptides of the hem­ agglutinin subunits (LAVER and WEBSTER, 1968) and it is likely that antigenic drift in the neuraminidase occurs by the same mechanism.

Keywords

Antigen Immunität biology diseases growth immunology microbiology peptides virus

Editors and affiliations

  • W. Arber
    • 1
  • W. Braun
    • 2
  • R. Haas
    • 3
  • W. Henle
    • 4
  • P. H. Hofschneider
    • 5
  • N. K. Jerne
    • 1
  • P. Koldovský
    • 4
  • H. Koprowski
    • 4
  • O. Maaløe
    • 6
  • R. Rott
    • 7
  • H. G. Schweiger
    • 8
  • M. Sela
    • 9
  • L. Svruček
    • 10
  • P. K. Vogt
    • 11
  • E. Wecker
    • 12
  1. 1.BasleSwitzerland
  2. 2.New BrunswickUSA
  3. 3.FreiburgGermany
  4. 4.PhiladelphiaUSA
  5. 5.MunichGermany
  6. 6.CopenhagenDenmark
  7. 7.GießenGermany
  8. 8.WilhelmshavenGermany
  9. 9.RehovotIsrael
  10. 10.PragueCzech Republic
  11. 11.Los AngelesUSA
  12. 12.WürzburgGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-65444-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1972
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-65446-6
  • Online ISBN 978-3-642-65444-2
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site