Tumor Biology

Regulation of Cell Growth, Differentiation and Genetics in Cancer

  • Asterios S. Tsiftsoglou
  • Alan C. Sartorelli
  • David E. Housman
  • T. Michael Dexter
Conference proceedings

Part of the NATO ASI Series book series (volume 99)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Martina Buck, Mario Chojkier
    Pages 1-3
  3. Mounira. K. Chelbi-Alix, Luis Pelicano, Frederique Quignon, Marcel Koken, Hugue de Thé
    Pages 17-27
  4. Kenji Fukasawa, Taesaeng Choi, George F. Vande Woude
    Pages 59-71
  5. Andrei L. Gartel, Medeia Gartel, Eugene Goufman, Angela L. Tyner
    Pages 73-80
  6. Frank Grosveld, Niall Dillon, Peter Fraser, John Strouboulis, Mark Wijgerde
    Pages 93-104
  7. Matthias W. Hentze
    Pages 105-112
  8. Sergio A. Lamprecht, Sarit Lifshitz, Sylvie Polak-Charcon, Bertha Schwartz
    Pages 167-175
  9. Leverrier Yann, Thomas Joëlle, Mangeney Marianne, Marvel Jacqueline
    Pages 177-181
  10. Jane Qiu, Paul R. Harrison
    Pages 227-233
  11. Jeffrey Ross, Philip Bernstein, Rebecca D. Prokipcak, David J. Herrick
    Pages 257-272
  12. Alan C. Sartorelli, Kimiko Ishiguro, Jianming Li, Debbie C. Koay, John A. Sokoloski
    Pages 285-293
  13. Asterios S. Tsiftsoglou, Ioannis S. Vizirianakis, Ioannis S. Pappas
    Pages 295-307
  14. A. L. Tyner, V. Vasioukhin, M. S. Serfas, E. Y. Siyanova, X. Llor
    Pages 309-318
  15. Back Matter
    Pages 329-336

About these proceedings


With the aim of providing an international forum for the communication of both the basic and clinical aspects of molecular and cellular biology of cancer, a NATO ASl was held in Porto Carras, Halkidiki, Greece, September 1-12, 1995. The principles as well as recent developments in tumor biology were discussed in depth, with emphasis on the regulation of the cell cycle, differentiation, programmed cell death (apoptosis) and genetics of cancer. This book constitutes the proceedings of that meeting. Specifically, the following areas were addressed: (a) enzymes and proteins (cyclins) that control the cell cycle, as well as the role of m as gene in meiosis and transformation; (b) the structural basis for specificity in protein-tyrosine kinase reactions; (c) the differentiation of normal as well as neoplastic cells with respect to molecular mechanism(s) by which chemical agents or growth factors trigger maturation; (d) phenotypic and genetic aspects of apoptosis; (e) the role of growth factors, like IGF-l, FGF, TN, IL-6, etc. , in cell cycle regulation, apoptosis (cell death) and senescence; (f) molecular mechanisms of transcriptional activation of globin genes and stability of mRNAs related to growth proteins and iron metabolism; (g) the cellular and molecular biology of bone marrow hemopoiesis; and (h) neurotrophic factors and the generation of cellular diversity in the central nervous system. It was obvious from the studies presented that neoplastic cell growth, differentiation and apoptosis in many cell types are regulated at several levels.


RNA apoptosis biology cancer cancer research cancer therapy cell cell death cell differentiation cellular differentiation gene expression protein proteins regulation tumor

Editors and affiliations

  • Asterios S. Tsiftsoglou
    • 1
  • Alan C. Sartorelli
    • 2
  • David E. Housman
    • 3
  • T. Michael Dexter
    • 4
  1. 1.Laboratory of Pharmacology, Department of Pharmaceutical SciencesAristotle University of ThessalonikiThessalonikiGreece
  2. 2.Department of PharmacologyYale University School of MedicineNew HavenUSA
  3. 3.Department of Biology, Center for Cancer ResearchMassachusetts Institute of TechnologyCambridgeUSA
  4. 4.Department of Experimental HematologyChristie Hospital, NHS Trust Paterson Institute for Cancer ResearchManchesterUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64735-2
  • Online ISBN 978-3-642-61180-3
  • Buy this book on publisher's site