Drug-Induced Hepatotoxicity

  • Ross G. Cameron
  • George Feuer
  • Felix A. de la Iglesia

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 121)

Table of contents

  1. Front Matter
    Pages I-XXXI
  2. R. G. Cameron, L. M. Blendis
    Pages 25-42
  3. R. W. Sallie, E. A. Jones
    Pages 75-97
  4. R. G. Thurman, P. E. Ganey, S. A. Belinsky, J. G. Conway, M. Z. Badr
    Pages 99-117
  5. J. S. Leeder, A. B. Okey
    Pages 119-153
  6. J. B. Watkins III, C. D. Klaassen
    Pages 155-171
  7. M. U. Dianzani
    Pages 185-210
  8. I. R. MacKay
    Pages 221-247
  9. A. S. Basile
    Pages 249-271
  10. F. Trevisani, D. H. van Thiel
    Pages 273-292
  11. E. A. Roberts
    Pages 293-322
  12. R. R. Varma
    Pages 323-340
  13. K. Kitani
    Pages 341-366
  14. P. G. Welling, W. F. Pool
    Pages 367-394
  15. T. F. Woolf, W. P. Pool, R. M. Walker, D. K. Monteith
    Pages 395-410
  16. M. Pirmohamed, B. K. Park
    Pages 411-440
  17. D. C. Snover
    Pages 441-455
  18. H. J. Zimmerman, K. G. Ishak
    Pages 457-476
  19. R. G. Cameron, F. A. de la Iglesia, G. Feuer
    Pages 477-513
  20. M. J. Zuckerman, S. Anuras
    Pages 515-542
  21. H. I. Zimmerman, K. G. Ishak
    Pages 543-579
  22. R. J. Fingerote, G. A. Levy
    Pages 581-609
  23. Y. Israel, E. Rubin
    Pages 611-636
  24. H. J. Zimmerman, K. G. Ishak
    Pages 637-662
  25. Back Matter
    Pages 663-683

About this book


The advances in science and medicine we are now experiencing are unprec­ edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho­ sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease. This is well recognized and is very important; indeed, removal of the offending agent can often lead to reversal of the adverse effect. This is an area of hepatology where we can really make a difference.


Hepatotoxizität Leber Reye's syndrome drug hepatoxicity liver toxicity

Editors and affiliations

  • Ross G. Cameron
    • 1
  • George Feuer
    • 2
  • Felix A. de la Iglesia
    • 3
  1. 1.Department of Pathology Division of Experimental PathologyUniversity of TorontoTorontoCanada
  2. 2.Department of Clinical Biochemistry Banting InstituteUniversity of TorontoTorontoCanada
  3. 3.Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental ToxicologyWarner Lambert CompanyAnn ArborUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1996
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64657-7
  • Online ISBN 978-3-642-61013-4
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site