Interacting Protein Domains

Their Role in Signal and Energy Transduction

  • Ludwig Heilmeyer

Part of the NATO ASI Series book series (volume 102)

Table of contents

  1. Front Matter
    Pages I-X
  2. Regulation by Reversible Protein Phosphorylation

    1. Front Matter
      Pages 1-1
    2. S. Jung, R. Hoffmann, T. Treptau, P. H. Rodriguez, B. G. Harris, P. F. Cook et al.
      Pages 19-24
  3. Methodology

  4. Phospholipid Signaling

    1. Front Matter
      Pages 73-73
    2. M. A. López-Ilasaca, J. S. Gutkind, M. A. Heidaran
      Pages 83-86
    3. Sue Goo Rhee, Yun Soo Bae
      Pages 87-92
    4. Dorthe da Graça Thrige, Jette Raun Byberg Buur, Flemming Steen Jørgensen
      Pages 93-96
  5. Tyrosine Phosphorylation and Downstream Signaling

    1. Front Matter
      Pages 105-105
    2. Christian Schoeberl, Edith Ossendorf, Joachim Kremerskothen, Charlotte Brewster, Steve Dilworth, Angelika Barnekow
      Pages 113-116
    3. Birgit Jaitner, Jörg Becker, Alfred Wittinghofer, Christoph Block
      Pages 139-142
    4. Javor P. Stolarov, Michael H. Wigler
      Pages 143-146
    5. Natalie G. Ahn, Scott C. Galasinski, Kristen K. Gloor, Timothy S. Lewis, Donna F. Louie, Sam J. Mansour et al.
      Pages 147-151
    6. Pamela M. Holland, Jonathan A. Cooper
      Pages 153-156
    7. Michael Kracht, Andrew Finch, Jeremy Saklatvala
      Pages 157-160
    8. Roger Meier, Mirjana Andjelković, Matthias Frech, Brian A. Hemmings
      Pages 161-170
    9. Patrick B. Dennis, George Thomas
      Pages 171-185
    10. Stefano Fumagalli, George Thomas
      Pages 187-194
    11. Nataša Andjelković, Stanislaw Zolnierowicz, Regina E. Mayer-Jaekel, Brian A. Hemmings
      Pages 195-206
  6. Regulatory Cascades

    1. Front Matter
      Pages 217-217
    2. Andrea Hülster, Franz-Werner Kluxen, Thomas Pfeuffer
      Pages 219-222
    3. Barry M. Willardson, Jon F. Wilkins, Tatsuro Yoshida, Mark W. Bitensky
      Pages 223-226
    4. Thomas Plath, Charlotte R. Knudsen, Nese Bilgin, Carsten Lindschau, Volker A. Erdmann, Corinna Lippmann
      Pages 231-234
    5. Lone Baunsgaard, Anja T. Fuglsang, Michael G. Palmgren
      Pages 235-238
  7. Regulation of Muscle Contraction

    1. Front Matter
      Pages 245-245
    2. A. D. Mehta, J. A. Spudich
      Pages 247-259
    3. Herwig Schüler, Elena Korenbaum, Uno Lindberg, Roger Karlsson
      Pages 261-264
    4. Andreas Teubner, Helmet E. Meyer, Albrecht Wegner
      Pages 265-268
    5. Ludwig M. G. Heilmeyer Jr., Karin Lohmann, Silke U. Reiffert, Kornelia Jaquet
      Pages 269-279
    6. Silke U. Reiffert, Kornelia Jaquet, Ludwig M. G. Heilmeyer Jr., Friedrich W. Herberg
      Pages 281-284
  8. Back Matter
    Pages 287-292

About these proceedings


This is now the fourth time that protein phosphorylation has been the focus of a NATO Advanced Study Institute. The first meeting with the topic "Signal Trans­ duction and Protein Phosphorylation" was held on the island of Spezai, Greece, in September 1986. The second one took place in Chateau La Londe, France, in September 1989 on "Cellular Regulation by Protein Phosphorylation", the third one on " Tyrosine Phosphorylation/Dephosphorylation and Downstream Signaling" was in September 1992 in Maratea, Italy. The titles of these books clearly mirror the developments that have taken place in the last decade. Beginning with the recognition that protein phosphorylation is at the center of signaling -clearly established in 1990 -it became apparent that many cellular processes are regulated by this mode. A new focus then emerged when it was recognized that growth factors are bound to corresponding receptors trigger protein tyrosine phosphorylation which controls cell prolifera­ tion. This was the topic of the third meeting in this series. It is now evident that further progress depends on understanding the three dimensional structure of the proteins involved. It goes without saying, for example, that understanding the location of proteins by adaptor proteins is only possible on the basis of the three dimensional protein structure. Therefore, the fourth meeting in this series concentrated on the protein structure of signaling molecules as well as on the elucidation of the principles of protein domain interactions.


ATP Activation Antigen FTIR-Spektroskopie Proteinphosphorylierung Proteinstruktur Vivo cellular processes enzymes opioid protein phosphorylation proteins regulation translation x-ray diffraction

Editors and affiliations

  • Ludwig Heilmeyer
    • 1
  1. 1.Institut für Physiologische Chemie Abt. Biochemie Supramolekularer SystemeRuhr-Universität BochumBochumGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64583-9
  • Online ISBN 978-3-642-60848-3
  • Buy this book on publisher's site