Applied Toxicology: Approaches Through Basic Science

Proceedings of the 1996 EUROTOX Congress Meeting Held in Alicante, Spain, September 22-25, 1996

  • Jürg P. Seiler
  • Eugenio Vilanova
Conference proceedings

Part of the Archives of Toxicology book series (TOXICOLOGY, volume 19)

Table of contents

  1. Front Matter
    Pages I-IX
  2. The Gerhard Zbinden Memorial Lecture

  3. Detection of Chemically-Induced Changes in P53 Expression

    1. Front Matter
      Pages 15-15
    2. Bertram Opalka, Sabine Kasimir-Bauer
      Pages 17-28
  4. Norman Aldridge Memorial Symposium

    1. Front Matter
      Pages 29-29
    2. A. Gómez de la Cámara, I. Abaitua Borda, M. Posada de la Paz
      Pages 31-40
    3. Rossanne M. Philen, Manuel Posada de la Paz, Robert H. Hill, Helen H. Schurz, Ignacio Abaitua Borda, Agustín Gómez de la Cámara et al.
      Pages 41-52
    4. Helen H. Schurz, Robert H. Hill, Rossanne M. Philen, Manuel Posada de la Paz, Ignacio Abaitua Borda, Edwin M. Kilbourne et al.
      Pages 53-64
    5. Carlos Lahoz, Victoria del Pozo, Soledad Gallardo, Blanca Cárdaba, Aurora Jurado, Isabel Cortegano et al.
      Pages 65-73
  5. Altered Gene Expression and Immunotoxicity

    1. Front Matter
      Pages 75-75
    2. Diels J. van den Dobbelsteen, C. Stefan I. Nobel, Andrew F. G. Slater, Sten Orrenius
      Pages 77-85
    3. Nathalie Auphan, Joseph A. Didonato, Arno Helmberg, Caridad Rosette, Michael Karin
      Pages 87-95
    4. Johan Garssen, Rob J. Vandebriel, Henk van Loveren
      Pages 97-109
  6. The Use of Ecotoxicology and Human Toxicology in the Regulation of Chemical Safety in the European Union

  7. Challenges in Analytical Toxicology

    1. Front Matter
      Pages 187-187
    2. Hans H. Maurer, Joachim W. Arlt, Thomas Kraemer, Christian J. Schmitt, Armin A. Weber
      Pages 189-197
  8. Air pollution and Allergy

    1. Front Matter
      Pages 199-199
    2. Thomas Nicolai, Erika von Mutius
      Pages 201-206
    3. P. A. Steerenberg, P. H. Fischer, L. van Bree, H. van Loveren
      Pages 207-216
  9. Prediction of Individual Susceptibility to Toxicants

    1. Front Matter
      Pages 217-217
  10. Cellular and Molecular Mechanisms of Cutaneous Toxicity

    1. Front Matter
      Pages 227-227
    2. Ian Kimber, Rebecca J. Dearman, Marie Cumberbatch
      Pages 229-238
    3. Miguel A. Miranda
      Pages 249-258
  11. Progress in Antidotic Therapy

    1. Front Matter
      Pages 259-259
    2. J. Pronczuk de Garbino
      Pages 261-270
    3. Frédéric J. Baud, Stephen W. Borron, Jean-Michel Scherrmann, Chantal Bismuth
      Pages 271-287
    4. Ana Ferrer, Emilia Civeira, Peña Lopez, Belen Loren
      Pages 289-298
    5. Dag Jacobsen, John A. Haines
      Pages 305-310
  12. In Vitro Cell models for investigating Molecular Mehanisms of Toxicity

    1. Front Matter
      Pages 311-311
    2. José V. Castell, María José Gómez-Lechón, Xavier Ponsoda, Roque Bort
      Pages 313-321
  13. Protein Targets of Neurotoxicity

    1. Front Matter
      Pages 323-323
    2. Hanna Tähti, Maria Engelke, Leila Vaalavirta
      Pages 337-345
    3. M. A. Sogorb, S. Bas, L. M. Gutiérrez, E. Vilanova, S. Viniegra
      Pages 347-355
  14. Carcinogenesis Mechanisms in Transgenic Mouse Models

    1. Front Matter
      Pages 357-357
    2. Snorri S. Thorgeirsson, Eric Santoni-Rugiu, Cindy D. Davis, Elizabeth G. Snyderwine
      Pages 359-366
    3. Ilona Kryspin Sørensen, Eva Kristiansen, Alicja Mortensen, Coen van Kreijl, Richard H. Adamson, Snorri S. Thorgeirsson
      Pages 377-386

About these proceedings


This volume contains the main papers presented at the 1996 EUROTOX congress, Alicante, Spain, September 22-25,1996.
The understanding of toxicological events, such as the Spanish Toxic Oil Syndrome, or of intoxications by algal toxins draws heavily on the knowledge obtained from basic science. This is clearly reflected in the topics of Symposia and Workshops that deal with alterations in gene expression and immunotoxicity, prediction of individual susceptibility to toxicants, mechanisms of phototoxicity, protein targets of neurotoxicity, as well as mechanisms of carcinogenesis in transgenic mice. The application of basic science then allows better evaluation of the role of air pollution in allergy or a better assessment of progress in antidotic therapy. A pivotal role is fulfilled here by methodological aspects of the detection of changes in gene expression, challenges in analytical toxicology, or the development of in vitro models for the study of molecular mechanisms of toxicity.


Immuntoxikologie Mechanismen der Toxizität Toxisches Öl-Syndrom apoptosis ecotoxicology enzymes gene expression immunotoxicology mechanisms of toxicity neurotoxicity toxic oil syndrome transgene Tiere transgenic animals Ökotoxikologie

Editors and affiliations

  • Jürg P. Seiler
    • 1
  • Eugenio Vilanova
    • 2
  1. 1.Interkantonale Kontrollstelle für HeilmittelSwitzerland
  2. 2.Dept. of Neurochemistry Campus San JuanUniversity of AlicanteAlicanteSpain

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64505-1
  • Online ISBN 978-3-642-60682-3
  • Series Print ISSN 0171-9750
  • Buy this book on publisher's site