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Connections, Cognition and Alzheimer’s Disease

  • B. T. Hayman
  • C. Duyckaerts
  • Y. Christen
Conference proceedings

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. C. Duyckaerts, M.-A. Colle, M. Bennecib, Y. Grignon, T. Uchihara, J.-J. Hauw
    Pages 33-39
  3. P. Vermersch, V. Buée-Scherrer, L. Buée, J. P. David, A. Wattez, N. Sergeant et al.
    Pages 41-52
  4. D. F. Swaab, P. J. Lucassen, J. A. P. van de Nes, R. Ravid, A. Salehi
    Pages 83-104
  5. D. Games, E. Masliah, M. Lee, K. Johnson-Wood, D. Schenk
    Pages 105-119
  6. E. Masliah, M. Mallory, M. Alford, R. DeTeresa, A. Iwai, T. Saitoh
    Pages 121-140
  7. T. Gomez-Isla, B. T. Hyman
    Pages 149-166
  8. J. V. Haxby, V. P. Clark, M. Courtney
    Pages 167-180
  9. A. R. Damasio, H. Damasio
    Pages 181-189
  10. Back Matter
    Pages 191-193

About these proceedings

Introduction

The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. Are neurofibrillary tangles and senile plaques directly related to clinical symptoms, or are they epiphenomena that signal synaptic and neuronal loss? In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation Ipsen which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology. .

Keywords

Alzheimer's disease Alzheimer´s disease aging brain cognition cortex cortical destruction cortical feedback dementia neural system neurodegenerative disorders synaptic disconnection

Editors and affiliations

  • B. T. Hayman
    • 1
  • C. Duyckaerts
    • 2
  • Y. Christen
    • 3
  1. 1.Nuerology ServiceMassachusetts General HospitalBostonUSA
  2. 2.Laboratoire de Neuropathologie R. EscourolleHôpital de La SalpêtrièreParis Cedex 16France
  3. 3.Fondation IPSENParis Cedex 16France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60680-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64504-4
  • Online ISBN 978-3-642-60680-9
  • Series Print ISSN 0945-6066
  • Buy this book on publisher's site