The Transplantation of Organs and Tissues Between Species

  • David K. C. Cooper
  • Ejvind Kemp
  • Jeffrey L. Platt
  • David J. G. White

Table of contents

  1. Front Matter
    Pages I-XXXIV
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. J. L. Platt, E. Kemp, D. K. C. Cooper
      Pages 2-5
  3. Immunobiology of Xenograft Rejection

    1. Front Matter
      Pages 7-7
    2. J. L. Platt
      Pages 8-16
    3. J. L. Platt, W. Parker, S. S. Lin, Z. Holzknecht, S. Saadi
      Pages 17-23
    4. R. Oriol, D. K. C. Cooper
      Pages 24-32
    5. T. D. H. Cairns, J. Lee, L. C. Goldberg, B. E. Samuelsson, D. H. Taube
      Pages 33-37
    6. A. P. Dalmasso
      Pages 38-60
    7. D. J. Goodman, M. T. Millan, C. Ferran, F. H. Bach
      Pages 77-94
    8. B. J. Hunt, K. M. Jurd
      Pages 126-139
    9. R. D. Moses, H. Auchincloss Jr.
      Pages 140-174
    10. M. L. Rose
      Pages 175-189
    11. S. A. Rollins, L. A. Matis
      Pages 190-198
    12. F. T. Thomas, W. Marchman, A. Carobbi, J. Contreras, J. George, E. Larkin et al.
      Pages 206-225
  4. Pathology of Xenograft Rejection

    1. Front Matter
      Pages 227-227
    2. S. Larsen, H. Starklint
      Pages 228-254
    3. Y. Luo, L. Mieles, S. D. Kosanke, D. K. C. Cooper
      Pages 287-302
  5. Experimental Xenotransplantation Between Closely Related Species

    1. Front Matter
      Pages 315-315
    2. J. A. Myburgh, J. A. Smit, J. H. Stark
      Pages 316-322
    3. B. Gridelli, S. Gatti, M. F. Donato, P. Andreani, L. R. Fassati, D. Galmarini
      Pages 323-327
    4. L. A. Valdivia, N. Murase, A. S. Rao, A. J. Demetris, J. J. Fung, T. E. Starzl
      Pages 328-338
  6. Experimental Xenotransplantation Between Widely Disparate Species

    1. Front Matter
      Pages 339-339
    2. F. A. Neethling, S. Taniguchi, S. F. Li, E. Koren, R. Oriol, R. D. Cummings et al.
      Pages 340-359
    3. E. Koren, F. Milotic, F. A. Neethling, D. K. C. Cooper
      Pages 377-386
    4. D. Faustman
      Pages 387-398
    5. M. Soares, X. Havaux, F. Cormont, F. Nisol, T. Besse, P. Gianello et al.
      Pages 399-410
    6. T. Kobayashi, E. Kemp, D. K. C. Cooper
      Pages 425-436
    7. A. S. Shah, S. Itescu, R. E. Michler
      Pages 456-462
    8. R. N. Pierson III, G. Pino-Chavez
      Pages 463-477
    9. J. S. Gammie, S. T. Ildstad
      Pages 519-531
  7. Experimental Pancreatic Islet Cell Xenotransplantation

    1. Front Matter
      Pages 533-533
    2. R. P. Lanza, W. L. Chick
      Pages 534-544
    3. F. T. Thomas
      Pages 545-564
    4. R. P. Lanza, W. L. Chick
      Pages 580-600

About this book


The success of transplantation in the treatment of human disease has increased the demand for organs and tissues far beyond the available supply. Xenotransplantation - the use of animals as donors - is viewed increasingly as the solution to this problem. Research into xenotransplantation has intensified greatly in the past five years since the first edition of this book was published. This second edition reflects this activity and provides a comprehensive overview of the current state of knowledge of the immunobiology of xenograft rejection and of the many therapeutic options being explored. Authored by the world's leading researchers, the volume is essential reading for anyone interested in the medical, scientific or ethical aspects of xenotransplantation. Many believe that we are on the threshold of clinical trials using genetically engineered animals as donors of organs. If successful, the rewards of clinical xenotransplantation will be immense and will represent one of the greatest medical advances of the modern era.


Genetic Engineering Heterografting Heterotransplantation Immunbiologie Transplantation Transplantationsimmunologie Xenogr experimental surgery experimentelle Chirurgie glycobiology immunobiology organ transplantation transplantation immunology

Editors and affiliations

  • David K. C. Cooper
    • 1
    • 2
  • Ejvind Kemp
    • 3
  • Jeffrey L. Platt
    • 4
  • David J. G. White
    • 5
    • 6
  1. 1.Immunologist (Surgery), Transplantation Biology Research CenterMassachusetts General Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Oklahoma Medical Research FoundationOklahoma CityUSA
  3. 3.Department of NephrologyOdense University HospitalOdenseDenmark
  4. 4.Departments of Surgery, Pediatrics and ImmunologyDuke University Medical CenterDurhamUSA
  5. 5.Department of SurgeryUniversity of CambridgeCambridgeUK
  6. 6.Imutran LaboratoriesCambridgeUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64460-3
  • Online ISBN 978-3-642-60572-7
  • Buy this book on publisher's site