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Drug Toxicity in Embryonic Development II

Advances in Understanding Mechanisms of Birth Defects: Mechanistic Understanding of Human Developmental Toxicants

  • Robert J. Kavlock
  • George P. Daston

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 124 / 2)

Table of contents

  1. Front Matter
    Pages I-XXV
  2. Pathogenesis and Mechanisms of Drug Toxicity in Development

    1. Front Matter
      Pages 1-1
    2. D. M. Kochhar
      Pages 3-39
    3. R. Neubert, D. Neubert
      Pages 41-119
    4. R. H. Finnell, B. Bielec, H. Nau
      Pages 121-159
    5. B. R. Danielsson, W. S. Webster
      Pages 161-190
    6. R. M. Pauli
      Pages 191-229
    7. R. Stahlmann, S. Klug
      Pages 231-264
    8. M. Fujinaga
      Pages 295-331
    9. J. M. Rogers, G. P. Daston
      Pages 333-405
  3. Back Matter
    Pages 475-485

About this book

Introduction

Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.

Keywords

Geburtsschaden Morphogenese abnormal development birth birth defects drug drugs embryo morphogenesis toxicity

Editors and affiliations

  • Robert J. Kavlock
    • 1
  • George P. Daston
    • 2
  1. 1.Reproductive Toxicology Division (MD-71) National Health and Environmental Effects Research LaboratoryUS Environmental Protection AgencyUSA
  2. 2.Miami Valley LaboratoriesThe Procter and Gamble CompanyCincinnatiUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60447-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64409-2
  • Online ISBN 978-3-642-60447-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site