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Interferons

Biological Activities and Clinical Efficacy

  • Carlo Aul
  • Wolfgang Schneider

Table of contents

  1. Front Matter
    Pages I-XIII
  2. C. Niederau, T. Heintges, F. Hensel, W. Petry, Ch. Niederau, D. Häussinger
    Pages 26-35
  3. B. Coiffier, F. Berger, F. Giles
    Pages 84-115
  4. C. S. Zent, H. M. Golomb
    Pages 132-138
  5. A. Heyll, D. Söhngen, K. A. Hollmig, C. Aul
    Pages 139-146
  6. H. Jablonowski
    Pages 196-216
  7. B. J. Schmitz-Dräger, F. Jankevicius, R. Ackermann
    Pages 217-249
  8. C. Aul, N. Gattermann, U. Germing, A. Heyll
    Pages 250-266
  9. Back Matter
    Pages 283-289

About these proceedings

Introduction

Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Although originally discovered as antiviral substances, interferons were soon employed in the treatment of tumors due to their antiproliferative, differentiation-inducing, and immunomodulatory properties. It was shown that those hematopoietic neoplasias which have been difficult to treat with chemotherapy, such as hairy cell leukemia, responded well to interferon treatment. The abundant data from 15 years of studying the significance of this therapeutic approach in hematooncology and other medical disciplines impressively demonstrate that progress in medicine is not the result of spectacular individual investigations, but rather results from longterm clinical research.
These are only preliminary findings, however, since still today there are many questions open pertaining to the clinical application of interferons - in particular their possible cumulative effect in combination with other cytokines or cytostatic drugs.
In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains an introduction to the genetics of the interferon system. Further chapters discuss the range of side effects of these substances and point out possible focuses for further clinical interferon research.

Keywords

Autoimmunerkrankungen HIV Hämato-Onkologie Interferon Interferone Internistische Pharmakotherapie Klassifikation Knochenmarktransplantation Nierenzellkarzinom Transplantation Tumorerkrankung autoimmune disease autoimmune diseases classification neuroendocrine tumors

Editors and affiliations

  • Carlo Aul
    • 1
  • Wolfgang Schneider
    • 1
  1. 1.Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60411-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-61051-9
  • Online ISBN 978-3-642-60411-9
  • Buy this book on publisher's site