Mechanisms of B Cell Neoplasia 1998

1. Chromosomal Translocations, DNA Rearrangement and Somatic Hypermutations

   1. Front Matter

      Pages 139-139

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   2. Phenotypic and Molecular Characterization of Human Peripheral Blood B-cell Subsets with Special Reference to N-Region Addition and Jκ-Usage in VκJκ-Joints and κ/λ-Ratios ixn Naive Versus Memory B-cell Subsets to Identify Traces of Receptor Editing Processes

      • U. Klein, K. Rajewsky, R. Küppers

      Pages 141-147

   3. Tuning Somatic Hypermutation by Transcription

      • H. Jacobs, A. Puglisi, K. Rajewsky, Y. Fukita

      Pages 149-159

   4. Immunoglobulin Gene Associated Chromosomal Translocations in B-Cell Derived Tumors

      • G. Klein

      Pages 161-167

   5. Analysis of B-cell Neoplasias by Spectral Karyotyping (SKY)

      • E. Hilgenfeld, H. Padilla-Nash, E. Schröck, T. Ried

      Pages 169-174

   6. Recurrent Non-reciprocal Translocations of Chromosome 5 in Primary T(12;15)-positive BALB/c Plasmacytomas

      • A. E. Coleman, T. Ried, S. Janz

      Pages 175-181

   7. MYC-Induced Cyclin D2 Genomic Instability in Murine B Cell Neoplasms

      • J. F. Mushinski, J. Hanley-Hyde, G. J. Rainey, T. I. Kuschak, C. Taylor, M. Fluri et al.

      Pages 183-192

   8. The Role of Somatic Hypermutation in the Generation of Deletions and Duplications in Human Ig V Region Genes and Chromosomal Translocations

      • R. Küppers, T. Goossens, U. Klein

      Pages 193-198

   9. Chromosome 13 Deletion in Myeloma

      • J. Shaughnessy, B. Barlogie

      Pages 199-203

   10. Unusual Immunoglobulin and T-cell Receptor Gene Rearrangement Patterns in Acute Lymphoblastic Leukemias

       • T. Szczepański, M. J. Pongers-Willemse, A. W. Langerak, J. J. M. van Dongen

       Pages 205-215

   11. Analysis of Variable Heavy and Light Chain Genes in Follicular Lymphomas of Different Heavy Chain Isotype

       • W. M. Aarts, R. J. Bende, S. T. Pals, C. J. M. van Noesel

       Pages 217-224

   12. Regulation of c-myc and Immunoglobulin κ Gene Transcription by Promoter-proximal Pausing of RNA Polymerase II

       • E. E. Schneider, T. Albert, D. A. Wolf, D. Eick

       Pages 225-231

2. Biology of Lymphomagenesis, B-CLL, Autoimmunity

   1. Front Matter

      Pages 233-233

      PDF

   2. Epidemiology of B-Cell Lymphomas

      • C. S. Rabkin

      Pages 235-240

   3. Alternative Splicing of CD79a (Igα) and CD79b (Igß Transcripts in Human B-CLL Cells

      • A. Alfarano, P. Circosta, A. Vallario, C. Camaschella, S. Indraccolo, A. Amadori et al.

      Pages 241-248

   4. Novel Aspects of Murine B Cell Lymphomas

      • H. C. Morse III, C.-F. Qi, L. Tadesse-Heath, S. K. Chattopadhyay, J. M. Ward, A. Coleman et al.

      Pages 249-255

   5. Molecular Pathogenesis of B Cell Malignancy: the Role of BCL-6

      • R. Dalla-Favera, A. Migliazza, C.-C. Chang, H. Niu, L. Pasqualucci, M. Butler et al.

      Pages 257-265

   6. ATM and Lymphoid Malignancies; Use of Oriented Peptide Libraries to Identify Novel Substrates of ATM Critical in Downstream Signaling Pathways

      • G. A. Rathbun, Y. Ziv, J. H. Lai, D. Hill, R. H. Abraham, Y. Shiloh et al.

      Pages 267-274

   7. MHC-linked Control of Murine SLE

      • N. Ibnou-Zekri, T. J. Vyse, S. J. Rozzo, M. Iwamoto, T. Kobayakawa, B. L. Kotzin et al.

      Pages 275-281

   8. The Adaptor Protein SLP-65/BLNK Controls the Calcium Response in Activated B Cells

      • B. Wollscheid, J. Wienands, M. Reth

      Pages 283-289

Workshops on the mechanisms of B cell neoplasia have been organized alternatively in Bethesda and Basel since 1983. Prog­ ress in our understanding of the development and responses of B lymphocytes is presented and discussed with the aim and hope to understand what might go wrong when B lymphocytes are transformed into malignant cells. Such knowledge might lead to better diagnosis, prevention and even cure of these terri­ ble diseases. The presentations at the Bethesda workshops are published as papers in volumes of Current Topics in Microbiol­ ogy and Immunology, while the presentations and discussions in Basel were transcribed and published in Editions Roche. For the first time, a Basel workshop (held 4th-6th October 1998) that has been recorded and, in part, transcribed is being published as papers and discussions within Current Topics. This volume is the latest of a long series which documents the excitements of ground-breaking discoveries as well as the frustrations of our inability to fully understand the mechanisms leading to B cell neoplasia. The papers at the workshop are presented when possible in the sequence in which they were given. However, to facilitate the organization and reading of the book and to highlight gen­ eral topics and themes, the papers are organized into five sec­ tions: I B Cell and Plasma Cell Development II Chemokines and Chemokine Receptors III Chromosomal Translocations, DNA Rearrangements and Somatic Hypermutations IV Biology of Lymphomagenesis, B-CLL, Autoimmunity V Myeloma, Plasmacytomas and Related Subjects.

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• Basel Institute for Immunology, Basel, Switzerland

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