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Metallopharmaceuticals II

Diagnosis and Therapy

  • Michael J. Clarke
  • Peter J. Sadler
Book

Part of the Topics in Biological Inorganic Chemistry book series (TBIC, volume 2)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Michael F. Tweedle, Krishan Kumar
    Pages 1-43
  3. Alan B. Packard, James F. Kronauge, Martin W. Brechbiel
    Pages 45-115
  4. Jeffrey T. Rhule, Craig L. Hill, Zhanmiao Zheng, Raymond F. Schinazi
    Pages 117-137
  5. K. H. Thompson, J. H. McNeill, C. Orvig
    Pages 139-158
  6. Hongzhe Sun, Peter J. Sadler
    Pages 159-185

About this book

Introduction

Inorganic compounds offer much scope for the design of novel and therapeutic agents. The widespread use of paramagnetic metal complexes as effective contrast agents for magentic resonsance imaging (e.g. Gd) demonstrates that the toxicity of metals can be finely controlled via the approriate choice of ligands. The succcessful targeting of radioisotopes again depends on ligand design and metal oxidation state. Bismuth and gold complexes have long been used in medicine but only recently have advances been made in understanding the molecular basis of their mechanism of action. New areas with clinical potential include the use of polyoxometallates and fullerenes as antiviral agents and vanadium complexes as insulin mimetics.

Keywords

Bioanorganische Chemie DNA Diagnostic Agents Inorganic Chemistry Metalle Metallopharmaceuticals Molecular Pharmacology Pharmaceuticals/Metallo biochemistry

Editors and affiliations

  • Michael J. Clarke
    • 1
  • Peter J. Sadler
    • 2
  1. 1.Department of ChemistryBoston CollegeChestnut HillUSA
  2. 2.Department of ChemistryUniversity of EdinburghEdinburghScotland, GB

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-60061-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-64239-5
  • Online ISBN 978-3-642-60061-6
  • Buy this book on publisher's site