Studies of Aging

  • Hal Sternberg
  • Paola S. Timiras

Part of the Springer Lab Manual book series (SLM)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Molecular Methods

    1. Front Matter
      Pages 1-1
    2. Alice Wong, Gino Cortopassi
      Pages 3-14
    3. J. J. Thiele, J. K. Lodge, J. H. Choi, L. Packer
      Pages 15-32
  3. Cellular Methods

    1. Front Matter
      Pages 33-33
    2. Judith Campisi
      Pages 35-45
    3. M. E. Harris-White, J. J. Sigel, S. A. Frautschy, Greg M. Cole
      Pages 46-57
    4. Richard A. Lockshin
      Pages 58-77
    5. Robert E. Monticone, Claudio Bilato, Michael T. Crow
      Pages 78-89
    6. Victor S. Sharov, Karlis Briviba, Helmut Sies
      Pages 90-101
  4. Animals Models

    1. Front Matter
      Pages 103-103
    2. Richard L. Sprott
      Pages 105-110
  5. Physiological Methods

    1. Front Matter
      Pages 125-125
    2. S. A. Frautschy, T. Chu, J. J. Sigel, M. E. Harris-White, G. M. Cole
      Pages 127-142
    3. Brian J. Merry
      Pages 143-163
    4. Sergio Scaccianoce, Raffaella Nicolai, Daniela Affricano, Katia Lombardo, Luciano Angelucci
      Pages 164-170
    5. Hal Sternberg, Paul Segall, Harold Waitz, Judith Segall
      Pages 171-181
  6. Back Matter
    Pages 207-208

About this book


Interest in the study of the biology of aging (Gerontology), especially as it relates to humans (Geriatrics), has increased steadily in the last 50 years and continues today to be at the forefront of experimental biology. Due to the many recent advances in this area, a large variety of techniques are available and selection of the best experimental approach may be difficult. It is the purpose of this laboratory manual to provide the researcher with a specific group of techniques with emphasis on practical, hands-on information.
A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimer's dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis (programmed cell death) for its role in cell death and aging processes.


Alzheimer's disease Alzheimer´s disease DNA Vivo aging cell cell death dementia geriatrics gerontology migration oxidative stress senescence skin tissue

Editors and affiliations

  • Hal Sternberg
    • 1
  • Paola S. Timiras
    • 2
  1. 1.BioTime Inc.BerkeleyUSA
  2. 2.Department of Molecular and Cell BiologyUniversity of CaliforniaBerkeleyUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-64600-6
  • Online ISBN 978-3-642-59916-3
  • Buy this book on publisher's site