Maturation Phenomenon in Cerebral Ischemia IV

Apoptosis and/or Necrosis, Neuronal Recovery vs. Death, and Protection Against Infarction

  • Nicolas G. Bazan
  • Umeo Ito
  • Victor L. Marcheselli
  • Toshihiko Kuroiwa
  • Igor Klatzo

Table of contents

  1. Front Matter
    Pages I-XVI
  2. The Role of Genetic Expression and Apoptosis

    1. Front Matter
      Pages 1-1
    2. C. Owen, C. Lipinski, A. Page, B. White, J. Sullivan, D. DeGracia et al.
      Pages 19-23
    3. A. Meisel, U. Dirnagl, M. Endres
      Pages 25-33
    4. R. M. McCarron, N. Bertrand, Y. Chen, A.-L. Siren, M. Spatz
      Pages 35-40
    5. R. P. Simon, J. Chen
      Pages 43-48
  3. Factors Modulating Neuronal Plasticity and Course of Maturation Phenomenon in Cerebral Ischemia (Metabolic and Inflammatory Factors)

    1. Front Matter
      Pages 49-49
    2. M. Chopp, Z. G. Zhang
      Pages 51-59
    3. H. Kato, K. Otsuka, T. Araki, T. Oikawa, A. Takahashi, Y. Itoyama
      Pages 61-69
    4. G. Mies, T. Trapp, E. Kilic, L. Oláh, R. Hata, D. M. Hermann et al.
      Pages 85-91
    5. B. R. Hu, M. E. Martone
      Pages 93-101
    6. K. Kogure, M. Izumiyama, T. Kogure, A. Maki, H. Itagaki, Y. Yamashita et al.
      Pages 103-110
  4. Factors and Mechanism Enhancing Susceptibility or Tolerance (Growth Factors)

  5. Ischemic Infarction: Threshold, Experimental and Clinical Dynamics and Therapeutic Design for Prevention and Reduction of Intensity

    1. Front Matter
      Pages 171-171
    2. R. Schmid-Elsaesser, S. Zausinger, T. Westermaier, E. Hungerhuber, A. Baethmann, H.-J. Reulen
      Pages 189-203
    3. C. Fieschi, F. Orzi, D. Toni
      Pages 205-209
  6. Mitochondrial Role in Ischemic Cell Death

    1. Front Matter
      Pages 211-211
    2. T. Sugawara, M. Fujimura, Y. Morita-Fujimura, M. Kawase, J. O. Kim, P. H. Chan
      Pages 213-221
    3. B. K. Siesjö, H. Uchino, T. Yoshimoto, B.-R. Hu, F. Shibasaki
      Pages 229-239
    4. E. W. Englander, J. R. Perez-Polo, G. H. Greeley Jr.
      Pages 241-251
    5. U. Ito, T. Kuroiwa, S. Hanyu, Y. Hakamata, S. Ito, I. Nakano et al.
      Pages 253-258
  7. Special Lecture

    1. Front Matter
      Pages 261-261
  8. Back Matter
    Pages 281-284

About these proceedings


The maturation phenomenon, first described by Ito et al. in 1975, refers to postischemic changes that develop hours or days after an ischemic insult. The delayed neuronal death of CA1 pyramidal cells of the hippocampus is a classic example. The report of the phenomenon boosted research in the field, as it became evident that ischemic damage is not a sudden event, but a process potentially susceptible to therapeutic intervention. Since then a growing number of studies have improved our knowledge on mechanisms of cell death and recovery. This volume contains the presentations of the 4th international symposium, held in New Orleans in October/November 1999, grouped in sections covering apoptosis and/or necrosis, neuronal recovery vs. death, and protection against infarction. It outlines the present status of investigations and provides further stimulation for research in this field.


Cerebral ischemia apoptosis cerebral infarction delayed neuronal death forebrain neuronal necrosis neurons

Authors and affiliations

  • Nicolas G. Bazan
    • 1
  • Umeo Ito
    • 2
  • Victor L. Marcheselli
    • 1
  • Toshihiko Kuroiwa
    • 3
  • Igor Klatzo
    • 4
  1. 1.Health Science Center Neuroscience Center of ExcellenceLouisiana State UniversityNew OrleansUSA
  2. 2.Department of NeurosurgeryMusashino Red Cross HospitalMusashino-shi TokyoJapan
  3. 3.Department of NeuropathologyTokyo Medical and Dental UniversityBunkyo-ku TokyoJapan
  4. 4.Laboratory of Neuropathology and Neuroanatomical SciencesNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-41107-9
  • Online ISBN 978-3-642-59446-5
  • Buy this book on publisher's site