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Immunization Against Alzheimer’s Disease and Other Neurodegenerative Disorders

  • Dennis J. Selkoe
  • Yves Christen
Conference proceedings

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. C. Cao, K. E. Ugen, C. Dickey, D. Wilcock, Y. Bai, M. N. Gordon et al.
    Pages 21-31
  3. C. Janus, H.-S. Johnson, J. McLaurin, P. Fraser, P. St. George-Hyslop, D. Westaway
    Pages 33-43
  4. C. A. Lemere, E. T. Spooner, J. F. Leverone, J. D. Clements
    Pages 59-74
  5. F. Bard, P. Seubert, D. Schenk, T. Yednock
    Pages 75-83
  6. D. M. Holtzman, K. R. Bales, S. M. Paul, R. B. DeMattos
    Pages 85-95
  7. D. Peretz, R. A. Williamson, K. Kaneko, D. R. Burton, S. B. Prusiner
    Pages 107-123
  8. Back Matter
    Pages 125-126

About these proceedings

Introduction

Promising effects in mice of immunization by ß-amyloid stimulated substantial research efforts and high hopes. In retrospect, this study appears simultaneously logical, consistent as it is with the amyloid theory central today in the field of Alzheimer's disease studies, and paradoxical, because it involved using the toxic substance itself for a treatment benefit. The research thus begun opens up multiple perspectives for experimentation and for treatment. Clinical trials began, but had to be stopped in January 2002 because of serious side effects. The editors' objective for this book is not to arouse false hopes for a therapeutic project that must still be proven, but to discuss the available information and the questions it raises.

Keywords

Alzheimer's disease Alzheimer´s disease Prions antibody clinical trial diagnosis immunization immunology microscopy neurodegenerative disorders pathogenesis plasma research treatment vaccination

Editors and affiliations

  • Dennis J. Selkoe
    • 1
  • Yves Christen
    • 2
  1. 1.Center for Neurologic DiseasesHarvard Medical School and Brigham and Women’s HospitalBostonUSA
  2. 2.Pour la Recherche ThérapeutiqueFondation IPSENParis Cedex 16France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-59332-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 2003
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-63937-1
  • Online ISBN 978-3-642-59332-1
  • Series Print ISSN 0945-6066
  • Buy this book on publisher's site