The Pineal Organ, Its Hormone Melatonin, and the Photoneuroendocrine System

  • H.-W. Korf
  • C. Schomerus
  • J. H. Stehle

Part of the Advances in Anatomy, Embryology and Cell Biology book series (ADVSANAT, volume 146)

Table of contents

  1. Front Matter
    Pages I-IX
  2. H.-W. Korf, C. Schomerus, J. H. Stehle
    Pages 1-8
  3. H.-W. Korf, C. Schomerus, J. H. Stehle
    Pages 9-11
  4. H.-W. Korf, C. Schomerus, J. H. Stehle
    Pages 13-44
  5. H.-W. Korf, C. Schomerus, J. H. Stehle
    Pages 73-77
  6. H.-W. Korf, C. Schomerus, J. H. Stehle
    Pages 79-79
  7. Back Matter
    Pages 81-101

About this book


This book offers a synoptic view of comparative anatomical, ultrastructural, cell and molecular biological investigations of the pineal organ. It considers morphological, immunocytochemical and functional features of pineal photoreceptors and neuroendocrine pinealocytes as well as the afferent and efferent innervation of the pineal organ. Special emphasis is placed on receptor mechanisms, second messenger systems (Ca2+ and cyclic AMP), transcription factors (e.g. cyclic AMP response element binding protein, CREB, and inducible cyclic AMP early repressor, ICER) and their roles for regulation of melatonin biosynthesis. Finally, the action, targets and receptors of melatonin are dealt with. The data presented stress the functional significance of the pineal organ and its hormoe melatonin as important components of the photoneuroendocrine system which allows man and animals to measure and keep the time. They also prove the pineal organ as a very suitable model to study signal transduction mechanisms in both photoreceptors and neuroendocrine cells by means of a variety of modern techniques.


Regulation anatomy biosynthesis cell biology melatonin biosynthesis molecular biology pineal photoreceptors pineal transcription factors transcription

Authors and affiliations

  • H.-W. Korf
    • 1
  • C. Schomerus
    • 1
  • J. H. Stehle
    • 1
  1. 1.Dr. Senckenbergische Anatomie Anatomisches Institut IIJohann Wolfgang Goethe-UniversitätFrankfurtGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-64135-3
  • Online ISBN 978-3-642-58932-4
  • Series Print ISSN 0301-5556
  • Series Online ISSN 2192-7065
  • Buy this book on publisher's site