Maturation Phenomenon in Cerebral Ischemia III

Defensive Mechanisms Versus Apoptosis Neuronal Recovery and Protection in Cerebral Infarction

  • Umeo Ito
  • Cesare Fieschi
  • Francesco Orzi
  • Toshihiko Kuroiwa
  • Igor Klatzo
Conference proceedings

Table of contents

  1. Front Matter
    Pages III-XVIII
  2. Role of Genetic Expression an Neuronal Apoptosis and/or Necrosis

    1. Front Matter
      Pages 1-1
    2. F. R. Sharp, M. Bergeron, J. Honkaniemi, A. Mancuso, S. Massa, P. R. Weinstein
      Pages 3-14
    3. W. C. Gordon, V. Colangelo, N. G. Bazan, I. Klatzo
      Pages 15-23
    4. C. Iadecola, M. E. Ross, F. Zhang, S. Nogawa, M. Nagayama, T. Nagayama
      Pages 25-31
    5. F. Gillardon, M. Spranger, R. Hata, C. Tiesler, K.-A. Hossmann
      Pages 33-39
    6. D. J. DeGracia, B. C. White, G. S. Krause
      Pages 47-52
    7. M. Kawase, K. Murakami, M. Fujimura, T. Kondo, Y. Morita-Fujimura, S. F. Chen et al.
      Pages 53-63
    8. K. Yamada, M. Nakatsuka, A. Masago, H. Taki
      Pages 65-68
  3. Factors and Mechanisms Enhancing Susceptibility or Tolerance (Growth Factors)

    1. Front Matter
      Pages 75-75
    2. M. Matsumoto, K. Kitagawa, M. Hori, T. Yanagihara
      Pages 87-93
    3. P. Schumann, K. Prass, F. Wiegand, M. Ahrens, D. Megow, U. Dirnagl
      Pages 95-103
    4. T. Miyazawa, K. Matsumoto, N. Tsuzuki, H. Nakau, T. Yamashima, K. Shima et al.
      Pages 117-123
  4. Factors Modulating Neuronal Plasticity and the Course of Maturation Phenomenon in Cerebral Ischemia (Metabolic and Inflammatory Factors)

    1. Front Matter
      Pages 125-125
    2. Y. Ohara, D. Dawson, H. Sugano, C. Ruetzler, N. Azzam, J. M. Hallenbeck et al.
      Pages 143-150
    3. M. Tomita, Y. Fukuuchi, N. Tanahashi, M. Kobari, H. Takeda, M. Yokoyama
      Pages 151-157
    4. E. Hungerhuber, S. Zausinger, A. Baethmann, H.-J. Reulen, R. Schmid-Elsaesser
      Pages 159-167
    5. B. J. Snider, J.-Y. Choi, D. M. Turetsky, L. M. T. Canzoniero, S. L. Sensi, C. T. Sheline et al.
      Pages 169-173
    6. A. Tamura, M. Nakane, T. Kuroiwa, T. Nagaoka, H. Nakanishi, T. Nakagomi et al.
      Pages 175-182
    7. K. Tanaka, Y. Fukuuchi, T. Shirai, H. Nozaki, E. Nagata, S. Suzuki et al.
      Pages 203-213
  5. Ischemic Infarction: Threshold, Experimental and Clinical Dynamics and Therapeutic Design for Prevention or Reduction of Intensity

    1. Front Matter
      Pages 215-215
    2. B. K. Siesjö, Y. Ouyang, T. Kristián, E. Elmér, P.-A. Li, H. Uchino
      Pages 217-225
    3. T. Kuroiwa, G. Mies, Y. Hakamata, S. Hanyu, R. Okeda, U. Ito
      Pages 237-241
    4. J. H. Garcia, Z.-R. Ye, K.-F. Liu, J. A. Gutierrez
      Pages 267-273
    5. T. Seiwert, A. Heimann, O. Kempski
      Pages 275-279
    6. C. Fieschi, C. Argentino, A. Falcou, M. Fiorelli, M. L. Sacchetti, G. Sette et al.
      Pages 281-287
  6. Special Lecture

    1. Front Matter
      Pages 289-289
  7. Poster Presentations (Abstracts)

    1. Front Matter
      Pages 309-309
    2. K. Takagi, A. Tamura, H. Nakayama, K. Narita, M. Aoki, T. Sato et al.
      Pages 311-311
    3. T. Asano, T. Matsui, E. Mori, A. Tamura, N. Tateishi, Y. Kagamiishi et al.
      Pages 315-315
    4. T. Dembo, K. Fukuuchi, K. Tanaka, T. Shirai, E. Nagata, D. Ito et al.
      Pages 319-320
    5. J. A. Gorter, E. M. Aronica, T. Opitz, M. V. L. Bennett, J. A. Connor, R. S. Zukin
      Pages 321-322
    6. R. Schmid-Elsaesser, E. Hungerhuber, S. Zausinger, A. Baethmann, H.-J. Reulen
      Pages 325-326

About these proceedings


The maturation phenomenon refers to postischemic changes that develop hours or days following an ischemic insult. The delayed neuronal death of CA1 pyramidical cells of the hippocampus is a classic example. The report of the phenomenon has boosted research in this field, as it became evident that ischemic damage is not a sudden event but a process potentially susceptible to therapeutic intervention. In September 1990, the first international symposium on "Maturation Phenomenon in Cerebral Ischemia" was held in Tokyo. The second symposium was organized in Tokyo in March/April 1996. Since then, new developments have rapidly delivered information about the molecular nature and dynamics of mechanisms concerning cell death and recovery. This book contains the presentations of the 3rd international symposium held in Pozilly/Italy in April 1998. It outlines the present status of the investigation and provides further stimulation for research in this field.


Cerebral ischemia adenosine apoptosis cerbral infarction delayed neuronal death forebrain neuronal necrosis neurons

Editors and affiliations

  • Umeo Ito
    • 1
  • Cesare Fieschi
    • 2
  • Francesco Orzi
    • 3
  • Toshihiko Kuroiwa
    • 4
  • Igor Klatzo
    • 5
  1. 1.Department of NeurosurgeryMusashino Red Cross HospitalTokyo 180Japan
  2. 2.Dipartimenti di Scienze NeurologicheUniversità di Roma “La Sapienza”RomaItaly
  3. 3.Istituto Neurologico MediterraneoNEUROMED Research LaboratoriesPozzilli (Isernia)Italy
  4. 4.Department of Neuropathology, Medical Research InstituteTokyo Medical and Dental University113 TokyoJapan
  5. 5.National Institutes of HealthLaboratory of Neuropathology and Neuroanatomical Sciences, NINDSBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1999
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-65023-2
  • Online ISBN 978-3-642-58602-6
  • Buy this book on publisher's site