The Pharmacology of Sleep

  • Anthony Kales

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 116)

Table of contents

  1. Front Matter
    Pages I-XXVIII
  2. R. Drucker-Colín, H. Merchant-Nancy
    Pages 1-28
  3. J. M. Monti
    Pages 117-142
  4. G. Tononi, O. Pompeiano
    Pages 143-210
  5. S. Inoué
    Pages 243-277
  6. E. Van Cauter
    Pages 279-306
  7. M. Radulovacki
    Pages 307-322
  8. E. O. Bixler, A. N. Vgontzas, A. Kales
    Pages 323-343
  9. A. Kales, A. N. Vgontzas, E. O. Bixler
    Pages 345-385
  10. A. Vela-Bueno
    Pages 387-419
  11. Y. Hishikawa
    Pages 421-442
  12. R. Fritsch Montero, D. Riemann, M. Berger
    Pages 465-490
  13. A. Baruzzi, F. Albani, R. Riva, E. Sforza, E. Lugaresi
    Pages 491-502
  14. A. N. Vgontzas, A. Kales
    Pages 503-536
  15. A. Kales, A. N. Vgontzas
    Pages 537-567
  16. Back Matter
    Pages 569-583

About this book


The last four decades have witnessed considerable advances in our knowledge of the pharmacology of sleep. Both basic and clinical pharmacology have made major contributions toward our current understanding of the complex mechanisms of sleep and wakefulness. In addition, these advances in our understanding of the pharmacology of sleep have benefited the treatment of sleep disorders and various neurologic and psychiatric conditions. This volume is organized into three different parts. The first is a review of the basic mechanisms of sleep and wakefulness and the chronobiology of sleep. The second part reviews the basic pharmacology of the various neuro­ transmitter systems involved in sleep and wakefulness, while the third is clinically oriented and focuses on the effects of a variety of drugs on sleep and wakefulness. The initial part begins with a historical review of the hypotheses of the mechanisms of sleep, evolving from passive to active regulation, and concepts involving sleep-related neurotransmitters and other sleep factors. Then regulation of sleep and wakefulness is discussed in terms of homeostatic, circadian, and ultradian processes. Also discussed is the fact that sleep homeostasis is not disrupted by the administration of hypnotic drugs. This part also reviews time-dependent properties of pharmacologic agents in relation to endogenous biologic rhythms and more specifically to chrono­ pharmacologic changes.


Deprivation Parkinson adenosine biochemistry biosynthesis catecholamines clonidine dopamine evolution forebrain interferon neurons physiology regulation thermoregulation

Editors and affiliations

  • Anthony Kales
    • 1
  1. 1.Sleep Research and Treatment CenterPennsylvania State University College of Medicine M.S. Hershey Medical CenterHersheyUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-63372-0
  • Online ISBN 978-3-642-57836-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site