Signal Transduction and the Coordination of B Lymphocyte Development and Function I

Transduction of BCR Signals from the Cell Membrane to the Nucleus

  • Louis B. Justement
  • Katherine A. Siminovitch

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 245/1)

Table of contents

  1. Front Matter
    Pages I-XV
  2. L. A. G. da Cruz, S. Penfold, J. Zhang, A.-K. Somani, F. Shi, M. K. H. McGavin et al.
    Pages 135-167
  3. J. Hagman, W. Wheat, D. Fitzsimmons, W. Hodsdon, J. Negri, F. Dizon
    Pages 169-194
  4. K. G. C. Smith, D. T. Fearon
    Pages 195-212
  5. K. M. Coggeshall
    Pages 213-260
  6. Back Matter
    Pages 261-267

About this book

Introduction

Proper development and differentiation of B lymphocytes is es­ sential to ensure that an organism has the ability to mount an effective humoral immune response against foreign antigens. The immune system must maintain a balance between the deletion of harmful self-reactive B cells and the generation of a diverse rep­ ertoire of B cells that has the ability to recognize an almost un­ limited array of foreign antigens. The need to delete self-reactive cells is tempered by the need to avoid the generation of large functional holes in the repertoire of foreign antigen-specific B cells that patrol the periphery. To accomplish this, the immune system must reach a compromise by eliminating only the most dangerous autoreactive clones, while allowing less harmful au­ toreactive B cells to exist in the periphery where they may com­ plement the organism's ability to mount a rapid response against invading micro-organisms. Those autoreactive cells that do enter the peripheral pool are subject to a number of conditional re­ straints that effectively attenuate their ability to respond to self­ antigens. Deleterious alterations in the homeostasis between tolerance induction and recruitment of B cells into the functional repertoire may lead to increased susceptibility to autoimmune disease or infection, respectively. Therefore, delineation of the molecular processes that maintain immunological homeostasis in the B cell compartment is critical.

Keywords

Activation Antigen cell cell biology cell membrane cytoskeleton gene gene expression lymphocytes membrane protein proteins regulation signal transduction transcription

Editors and affiliations

  • Louis B. Justement
    • 1
  • Katherine A. Siminovitch
    • 2
  1. 1.Division of Developmental & Clinical Immunology Department of MicrobiologyUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of MedicineUniversity of Toronto Mount Sinai HospitalTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-57066-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-63017-0
  • Online ISBN 978-3-642-57066-7
  • Series Print ISSN 0070-217X
  • About this book