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Protein Degradation in Health and Disease

  • Michèle Reboud-Ravaux

Part of the Progress in Molecular and Subcellular Biology book series (PMSB, volume 29)

Table of contents

  1. Front Matter
    Pages I-X
  2. Takumi Kamura, Joan W. Conaway, Ronald C. Conaway
    Pages 1-15
  3. Bertrand Friguet
    Pages 17-33
  4. Walter F. Ward
    Pages 35-42
  5. Teruyuki Tsuji, Shun Shimohama
    Pages 43-60
  6. Richard K. Plemper, Anthea L. Hammond
    Pages 61-84
  7. Olivier Coux
    Pages 85-107
  8. Michèle Reboud-Ravaux
    Pages 109-125
  9. Back Matter
    Pages 127-130

About this book

Introduction

Protein degradation has been identified as a centerpiece of regulation of cell functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Keywords

Krebs Proteinabbau aging alzheimer's disease cancer cell central nervous system development diseases metabolism pathology proliferation protein proteins regulation

Editors and affiliations

  • Michèle Reboud-Ravaux
    • 1
  1. 1.Laboratoire d’Enzymologie Moléculaire et Fonctionnelle Département de Biologie Cellulaire Institut Jacques MonodUniversités Paris VI & VIIParis Cedex 05France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-56373-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62714-9
  • Online ISBN 978-3-642-56373-7
  • Series Print ISSN 0079-6484
  • Buy this book on publisher's site