Mechanisms of Organ Dysfunction in Critical Illness

  • Timothy W. Evans
  • Mitchell P. Fink
Part of the Update in Intensive Care and Emergency Medicine book series (volume 38)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Mitochondrial Biology

    1. Front Matter
      Pages 1-1
    2. A. P. Halestrap, A. O’Toole, K. Lim
      Pages 17-39
    3. X. M. Leverve
      Pages 52-68
    4. J. M. Weinberg, M. A. Venkatachalam, I. Nissim
      Pages 69-91
  3. Leukocytes and Cell Signaling Mechanisms in Inflammation

  4. Microcirculatory Dysfunction

    1. Front Matter
      Pages 173-173
    2. B. Vallet, E. Wiel, P.-A. Rodie-Talbère
      Pages 175-190
    3. A. W. Sielenkämper, C. G. Ellis, P. Kvietys
      Pages 191-202
  5. Lung and Kidney

    1. Front Matter
      Pages 203-203
    2. S. J. Finney, S. J. Wort, T. W. Evans
      Pages 205-221

About this book

Introduction

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

Keywords

Sepsis Trauma brain injury cerebral ischemia hypoxia mechanical ventilation multiple organ failure shock

Editors and affiliations

  • Timothy W. Evans
    • 1
  • Mitchell P. Fink
    • 2
  1. 1.Intensive Care UnitRoyal Brompton HospitalLondonUK
  2. 2.Division of Critical Care MedicineUniversity of Pittsburgh Medical CenterPittsburghUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-56107-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-42692-9
  • Online ISBN 978-3-642-56107-8
  • Series Print ISSN 0933-6788