Arenaviruses II

The Molecular Pathogenesis of Arenavirus Infections

  • Michael B. A. Oldstone

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 263)

Table of contents

About this book

Introduction

Viruses are studied either because they cause significant human, animal or plant disease or because they are useful materials for probing basic phenomena in biology, chemistry, genetics and/or molecular biology. Arenaviruses are unusually interesting in that they occupy both categories. Arenaviruses cause several human diseases known primarily as the hemorrhagic fevers occurring in South and Latin America (Bolivia: Machupo, Argentine, Junin virus, and Brazil: Sabia virus) and in Africa (Lassa fever virus). Because such viruses produce profound disabilities and often kill the persons they infect, they are a source of health concern and economic hardship in the countries where they are prevalent. Further, they provide new problems for healthcare persons owing to the narrowing of the world as visitors from many countries travel increasingly to and from endemic areas and may incubate the infectious agent taking it from an endemic area into an area where the virus is not expected. Such cases are now being re­ corded with increasing frequency. In addition to these hemor­ rhagic fever viruses, the arenavirus lymphocytic choriomeningitis virus (LCMV) can infect humans worldwide, although the illness is most often less disabling and severe than those elicited by the other arenaviruses. Yet, LCMV is of greater concern to non­ arenavirologists and experimentalists using tissue culture or ani­ mals, etc. , because normal-appearing cultured cells or tissues from animals used for research may be persistently infected with LCMV without manifesting clinical disease or cytopathology and may transmit that infection to laboratory workers.

Keywords

antibody autoimmunity bacteria cytokine cytokines immune response immunity immunology infection parasite pathogenesis pathology physiology vaccine virus

Editors and affiliations

  • Michael B. A. Oldstone
    • 1
  1. 1.Division of Virology Department of NeuropharmacologyThe Scripps Research InstituteLa JollaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-56055-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62724-8
  • Online ISBN 978-3-642-56055-2
  • Series Print ISSN 0070-217X
  • About this book