Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate

  • Yves Christen
  • Alain Israël
  • Bart De Strooper
  • Frédéric Checler

Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. N. Gupta-Rossi, O. Le Bail, Ch. Brou, F. Logeat, E. Six, A. Israël
    Pages 41-58
  3. H. Steiner, M. Sastre, G. Multhaup, D. B. Teplow, Ch. Haass
    Pages 59-61
  4. A. Petit, F. Bihel, C. Alves da Costa, O. Pourquié, Y.-H. Suh, J.-L. Kraus et al.
    Pages 63-70
  5. M. S. Wolfe, W. P. Esler, W. T. Kimberly, D. J. Selkoe
    Pages 71-87
  6. C. Esselens, V. Baert, C. Boeve, G. Snellings, P. Cupers, K. Craessaerts et al.
    Pages 89-99
  7. F. Chen, G. Yu, S. Arawaka, M. Nishimura, T. Kawarai, H. Yu et al.
    Pages 109-117
  8. E. H. Koo, S. Soriano, D. E. Kang
    Pages 119-129
  9. K. S. Kosik, M. Medina, T. Ochiishi, M. C. Martinez, Q. Lu
    Pages 131-141
  10. A. Joutel, F. Andreux, A. Francois, V. Domenga, F. Chapon, C. Godfraind et al.
    Pages 143-156
  11. Back Matter
    Pages 157-158

About these proceedings


Can molecular mechanisms involved in neural development help us to understand, prevent and perhaps reverse the course of brain ageing and neurodegenerative disorders? Brain development and function require complex cellular and molecular processes controlled by a number of different signaling mechanisms. One such signaling mechanism, the Notch pathway, has been recognized as an important player in the regulation of cellfate decisions during early neural development. However, the action of this evolutionary conserved and widely used cell-cell interaction mechanism is not confined to the developing nervous system. In addition, recent studies have shown that elucidating the mechanism of Notch signaling and its role in the brain is important for our understanding of neurological disorders such as Alzheimer's disease and cerebral arteriopathy CADASIL.


ALzheimer's Disease Nervous System Proteolysis neurons nicastrin presenilin ubiquitin-proteasome pathway

Editors and affiliations

  • Yves Christen
    • 1
  • Alain Israël
    • 2
  • Bart De Strooper
    • 3
  • Frédéric Checler
    • 4
  1. 1.Fondation IPSENPour la Recherche ThérapeutiqueParis Cedex 16France
  2. 2.Institut PasteurUnité de Biologie Moléculaire de l’Expression Génique URA 1773 CNRSParis Cedex 15France
  3. 3.Laboratory for Neuronal Cell Biology Center for Human GeneticsKUL-Gasthuisberg and Flanders Interuniversity Institute for BiotechnologyLeuvenBelgium
  4. 4.Institut de PharmacologieMoléculaire et Cellulaire CNRS UPR 411Sophia Antipolis, ValbonneFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-62767-5
  • Online ISBN 978-3-642-55996-9
  • Series Print ISSN 0945-6066
  • Buy this book on publisher's site