Book 2014

Developments in Statistical Evaluation of Clinical Trials

Editors:

ISBN: 978-3-642-55344-8 (Print) 978-3-642-55345-5 (Online)

Table of contents (18 chapters)

  1. Front Matter

    Pages i-xi

  2. No Access

    Chapter

    Pages 1-27

    Statistical Models and Methods for Incomplete Data in Randomized Clinical Trials

  3. No Access

    Chapter

    Pages 29-50

    Bayesian Decision Theory and the Design and Analysis of Randomized Clinical Trials

  4. No Access

    Chapter

    Pages 51-69

    Designing Multi-arm Multi-stage Clinical Studies

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    Chapter

    Pages 71-84

    Statistical Approaches to Improving Trial Efficiency and Conduct

  6. No Access

    Chapter

    Pages 85-96

    Competing Risks and Survival Analysis

  7. No Access

    Chapter

    Pages 97-118

    Recent Developments in Group-Sequential Designs

  8. No Access

    Chapter

    Pages 119-137

    Statistical Inference for Non-inferiority of a Diagnostic Procedure Compared to an Alternative Procedure, Based on the Difference in Correlated Proportions from Multiple Raters

  9. No Access

    Chapter

    Pages 139-151

    Design and Analysis of Clinical Trial Simulations

  10. No Access

    Chapter

    Pages 153-175

    Causal Effect Estimation and Dose Adjustment in Exposure-Response Relationship Analysis

  11. No Access

    Chapter

    Pages 177-193

    Different Methods to Analyse the Results of a Randomized Controlled Trial with More Than One Follow-Up Measurement

  12. No Access

    Chapter

    Pages 195-207

    Statistical Methods for the Assessment of Clinical Relevance

  13. No Access

    Chapter

    Pages 209-226

    Statistical Considerations in the Use of Composite Endpoints in Time to Event Analyses

  14. No Access

    Chapter

    Pages 227-246

    Statistical Validation of Surrogate Markers in Clinical Trials

  15. No Access

    Chapter

    Pages 247-263

    Biomarker-Based Designs of Phase III Clinical Trials for Personalized Medicine

  16. No Access

    Chapter

    Pages 265-282

    Dose-Finding Methods for Two-Agent Combination Phase I Trials

  17. No Access

    Chapter

    Pages 283-304

    Multi-state Models Used in Oncology Trials

  18. No Access

    Chapter

    Pages 305-333

    Review of Designs for Accommodating Patients’ or Physicians’ Preferences in Randomized Controlled Trials

  19. No Access

    Chapter

    Pages 335-361

    Dose Finding Methods in Oncology: From the Maximum Tolerated Dose to the Recommended Phase II Dose