Developments in Statistical Evaluation of Clinical Trials

  • Kees van Montfort
  • Johan Oud
  • Wendimagegn Ghidey

Table of contents

  1. Front Matter
    Pages i-xi
  2. Janice Pogue, P. J. Devereaux, Salim Yusuf
    Pages 71-84
  3. Kees van Montfort, Peter Fennema, Wendimagegn Ghidey
    Pages 85-96
  4. James M. S. Wason
    Pages 97-118
  5. Kazuhiko Kuribayashi
    Pages 139-151
  6. Ariel Alonso, Geert Molenberghs, Gerard van Breukelen
    Pages 227-246
  7. Shigeyuki Matsui, Takahiro Nonaka, Yuki Choai
    Pages 247-263
  8. Akihiro Hirakawa, Shigeyuki Matsui
    Pages 265-282
  9. Birgit Gaschler-Markefski, Karin Schiefele, Julia Hocke, Frank Fleischer
    Pages 283-304

About this book


This book describes various ways of approaching and interpreting the data produced by clinical trial studies, with a special emphasis on the essential role that biostatistics plays in clinical trials.

Over the past few decades the role of statistics in the evaluation and interpretation of clinical data has become of paramount importance. As a result the standards of clinical study design, conduct and interpretation have undergone substantial improvement. The book includes 18 carefully reviewed chapters on recent developments in clinical trials and their statistical evaluation, with each chapter providing one or more examples involving typical data sets, enabling readers to apply the proposed procedures. The chapters employ a uniform style to enhance comparability between the approaches.


clinical trials dose adjustment survival analysis

Editors and affiliations

  • Kees van Montfort
    • 1
  • Johan Oud
    • 2
  • Wendimagegn Ghidey
    • 3
  1. 1.Department of BiostatisticsErasmus Medical CenterRotterdamThe Netherlands
  2. 2.Behavioural Science InstituteUniversity of NijmegenNijmegenThe Netherlands
  3. 3.Department of HematologyErasmus Medical CenterRotterdamThe Netherlands

Bibliographic information