Nucleic Acids in the Gas Phase

  • Valérie Gabelica

Part of the Physical Chemistry in Action book series (PCIA)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Methods

    1. Front Matter
      Pages 1-1
    2. Gilles Grégoire
      Pages 21-54
    3. Annalisa Arcella, Guillem Portella, Modesto Orozco
      Pages 55-75
    4. Valérie Gabelica, Frédéric Rosu
      Pages 103-130
    5. Yang Gao, Scott A. McLuckey
      Pages 131-182
  3. Applications

  4. Back Matter
    Pages 283-287

About this book


This book gives physical chemists a broader view of potential biological applications of their techniques for the study of nucleic acids in the gas phase. It provides organic chemists, biophysicists, and pharmacologists with an introduction to new techniques they can use to find the answers to yet unsolved questions. Laboratory sciences have bloomed with a variety of techniques to decipher the properties of the molecules of life. This volume introduces techniques used to investigate the properties of nucleic acids in the absence of solvent. It highlights the specificities pertaining to the studies of nucleic acids, although some of the techniques can similarly be applied to the study of other biomolecules, like proteins. The first part of the book introduces the techniques, from the transfer of nucleic acids to the gas-phase, to their detailed physico-chemical investigation. Each chapter is devoted to a specific molecular property, and illustrates how various approaches (experimental and theoretical) can be combined for the interpretation.
The second part of the book is devoted to applying the gas-phase approaches to solve specific questions related to the biophysics, biochemistry or pharmacology of nucleic acids.


Electron Attachment Fragmentation Reactions Ionizing Radiation Damage Metal Ions and Nucleic Acids Nucleic Acids Ligand Binding Nucleic Acids Mass Spectrometry Nucleic Acids Spectroscopy RNA Sequencing RNA/DNA

Editors and affiliations

  • Valérie Gabelica
    • 1
  1. 1.Université de BordeauxInstitut Européen de Chimie et BiologiePessacFrance

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-642-54841-3
  • Online ISBN 978-3-642-54842-0
  • Series Print ISSN 2197-4349
  • Series Online ISSN 2197-4357
  • Buy this book on publisher's site