Clinical Neuroembryology

Development and Developmental Disorders of the Human Central Nervous System

  • Hans J. ten Donkelaar
  • Martin Lammens
  • Akira Hori

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Hans J. ten Donkelaar, Shigehito Yamada, Kohei Shiota, Ton van der Vliet
    Pages 1-52
  3. Hans J. ten Donkelaar
    Pages 53-104
  4. Martin Lammens, John M. G. van Vugt, Michèl Willemsen, Patrick van der Voorn, Hans van Bokhoven, Hans J. ten Donkelaar
    Pages 105-164
  5. Hans J. ten Donkelaar, Mireille Bekker, Willy O. Renier, Akira Hori, Kohei Shiota
    Pages 165-217
  6. Hans J. ten Donkelaar, Christl Vermeij-Keers, Irene M. J. Mathijssen
    Pages 219-269
  7. Hans J. ten Donkelaar, Kyoko Itoh, Akira Hori
    Pages 271-320
  8. Hans J. ten Donkelaar, Johannes R. M. Cruysberg, Ronald Pennings, Martin Lammens
    Pages 321-370
  9. Hans J. ten Donkelaar, Martin Lammens, Pieter Wesseling, Akira Hori
    Pages 371-420
  10. Hans J. ten Donkelaar, Martin Lammens, Johannes R. M. Cruysberg, Karin Kamphuis-van Ulzen, Akira Hori, Kohei Shiota
    Pages 421-521
  11. Hans J. ten Donkelaar, Martin Lammens, Eleonora Aronica, Hans van Bokhoven, Karin Kamphuis-van Ulzen, Akira Hori
    Pages 523-642
  12. Back Matter
    Pages 643-659

About this book


This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental, and hypoxic/ischemic causes. The introductory chapters give an overview of the development of the human brain and the spinal cord, the mechanisms of development as obtained in experimental studies of various invertebrates and vertebrates, and  the causes of congenital malformations. In the main part, the developmental disorders of the human brain and the spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These are underlined by carefully chosen clinical case studies, including imaging data and, when available, postmortem verification of the developmental disorders involved. Numerous color photographs and illustrations complement the text.

This second edition emphasizes the prenatal diagnosis by ultrasound, MRI, and DTI and implements new classifications of developmental disorders.


Brain stem Central nervous system Cerebral cortex Developmental disorders Forebrain Genetic disorders Human cerebellum Human embryology Malformation Neuropathology Spinal cord

Authors and affiliations

  • Hans J. ten Donkelaar
    • 1
  • Martin Lammens
    • 2
  • Akira Hori
    • 3
  1. 1.935 Dept. NeurologyRadboud University Nijmegen Medical CenterNijmegenThe Netherlands
  2. 2.Department of PathologyUniversity Hospital AntwerpenEdegemBelgium
  3. 3.Research Institute for Longevity MedicineFukushimura HospitalToyohashiJapan

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-54686-0
  • Online ISBN 978-3-642-54687-7
  • Buy this book on publisher's site