Small Molecules in Oncology

  • Uwe M. Martens
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 201)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Cornelius F. Waller
    Pages 1-25
  3. Markus Lindauer, Andreas Hochhaus
    Pages 27-65
  4. Benjamin N. Ostendorf, Philipp le Coutre, Theo D. Kim, Alfonso Quintás-Cardama
    Pages 67-80
  5. Susanne Isfort, Gunhild Keller-v. Amsberg, Philippe Schafhausen, Steffen Koschmieder, Tim H. Brümmendorf
    Pages 81-97
  6. Julius Wehrle, Heike L. Pahl, Nikolas von Bubnoff
    Pages 99-107
  7. M. Steins, M. Thomas, M. Geißler
    Pages 109-123
  8. Minna Nolting, Tanja Schneider-Merck, Martin Trepel
    Pages 125-143
  9. Amal Imbulgoda, Daniel Y. C. Heng, Christian Kollmannsberger
    Pages 165-184
  10. Thomas J. Ettrich, Thomas Seufferlein
    Pages 185-196
  11. David F. Heigener, Martin Reck
    Pages 197-205
  12. Claus Garbe, Sail Abusaif, Thomas K. Eigentler
    Pages 215-225
  13. Radhika Kainthla, Kevin B. Kim, Gerald S. Falchook
    Pages 227-240
  14. Robert Zeiser
    Pages 241-248
  15. Heiko Becker, Monika Engelhardt, Nikolas von Bubnoff, Ralph Wäsch
    Pages 249-257
  16. Mark-Alexander Schwarzbich, Matthias Witzens-Harig
    Pages 259-267
  17. Björn Hackanson, Michael Daskalakis
    Pages 269-297
  18. Antonia M. S. Müller, Mareike Florek
    Pages 299-324

About this book

Introduction

Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.

Keywords

Molecular mechanisms of cancer Oncogenic protein kinase inhibitors Targeted therapy Treatment of malignant diseases

Editors and affiliations

  • Uwe M. Martens
    • 1
  1. 1.Cancer Center Heilbronn-FrankenSLK-Kliniken Heilbronn GmbH Medizinische Klinik IIIHeilbronnGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-54490-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-54489-7
  • Online ISBN 978-3-642-54490-3
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • About this book