Basic Science, Epidemiology, Clinical Aspects and Management

  • Jacob P. Thyssen
  • Howard I. Maibach

Table of contents

  1. Front Matter
    Pages i-xv
  2. Basic Science

    1. Front Matter
      Pages 1-1
    2. Jakob Mutanu Jungersted
      Pages 23-26
    3. Christian Vestergaard, Mette S. Deleuran
      Pages 27-36
    4. Charlotte M. Bonefeld, Morten M. Nielsen, Carsten Geisler
      Pages 37-47
    5. Jens-Michael Schröder, Britta Hansmann
      Pages 49-62
  3. Identification and Study Methods

    1. Front Matter
      Pages 63-63
    2. Kozo Nakai, Kozo Yoneda, Yasuo Kubota
      Pages 65-74
    3. Pal B. Szecsi, Michael Meldgaard
      Pages 103-116
  4. Epidemiology and Environmental Exposures

    1. Front Matter
      Pages 117-117
    2. Marten C. G. Winge, Maria Bradley
      Pages 119-128
    3. Ruhong Cheng, Ming Li, Hui Zhang, Zhirong Yao
      Pages 129-135
  5. Filaggrin and Atopic Disease

    1. Front Matter
      Pages 141-141
    2. Jennifer R. Heimall, Jonathan M. Spergel
      Pages 143-151
    3. Teresa Tsakok, Carsten Flohr
      Pages 153-168
    4. Simon F. Thomsen
      Pages 169-181
    5. Tatiana A. Vogel, Marie-Louise A. Schuttelaar
      Pages 183-193
    6. Hern Tze Tina Tan, Katrina J. Allen
      Pages 195-207
    7. Gunnaporn Suriyaphol, Sirin Theerawatanasirikul, Prapat Suriyaphol
      Pages 209-219
  6. Filaggrin and Cutaneous Disease

    1. Front Matter
      Pages 221-221
    2. Sreya Talasila, Amy S. Paller
      Pages 223-234
    3. Wolfgang J. C. Uter
      Pages 251-257
    4. Sanja Kezic, Maaike J. Visser
      Pages 259-262
    5. Richard Brans, Swen Malte John
      Pages 263-271
    6. Peter Jensen, Lone Skov
      Pages 273-277
    7. Emily Y. Gan, Sophie C. S. Cai, Mark B. Y. Tang
      Pages 279-291
    8. Lennart Emtestam, Lena Hagströmer, Karin Sartorius
      Pages 293-299
    9. David Bregnbak, Claus O. C. Zachariae, Torkil Menné
      Pages 301-307
  7. Filaggrin and Non-cutaneous Disease

    1. Front Matter
      Pages 309-309
    2. Elena Godoy-Gijón
      Pages 311-320
    3. Anne Sofie Lund Bateman, Steffen Heegaard
      Pages 321-325
    4. Simon W. Fage, Thomas Iftner, Jacob P. Thyssen, Susanne K. Kjaer
      Pages 333-342
    5. Katleen F. E. Van Steendam, Dieter L. Deforce
      Pages 343-349
    6. Anne Marie Lynge Pedersen, Jesper Reibel
      Pages 351-356
  8. Management

    1. Front Matter
      Pages 357-357
    2. Berit Christina Carlsen
      Pages 359-373

About this book


Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.


Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. 


This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.


Clinical disease Disease patterns Ichthyosis vulgaris Treatment

Editors and affiliations

  • Jacob P. Thyssen
    • 1
  • Howard I. Maibach
    • 2
  1. 1.Department of Dermato-AllergologyNational Allergy Research Centre, Gentofte Hospital, University of CopenhagenHellerupDenmark
  2. 2.Department of DermatologyUniversity of CaliforniaSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-54378-4
  • Online ISBN 978-3-642-54379-1
  • Buy this book on publisher's site