Total Synthesis of (±)-Maoecrystal V

  • Jianxian Gong
Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Jianxian Gong
    Pages 29-71
  3. Jianxian Gong
    Pages 73-135
  4. Jianxian Gong
    Pages 137-137

About this book

Introduction

In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereoselective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.

Keywords

Intramolecular Diels-Alder Reaction Maoecrystal V Natural Product Pinhey Arylation Stereoselective Tetrahydrofuran Oxa-Bridge Skeleton Total Synthesis Wessely Oxidative Dearomatization

Authors and affiliations

  • Jianxian Gong
    • 1
  1. 1.School of Chemical Biology & BiotechnologyPeking University Shenzhen Graduate School (PKUSZ)ShenzhenChina

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-54304-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-642-54303-6
  • Online ISBN 978-3-642-54304-3
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • About this book