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Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards

The Use of Short-Term Tests for Mutagenicity and Carcinogenicity in Chemical Hazard Evaluation

  • H. C. Grice

Part of the Current Issues in Toxicology book series (CI TOXICOLOGY)

About this book

Introduction

The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by pro­ viding the mechanism for scientists from government, industry and universities to work together on cooperative programs to generate and disseminate scientific data. The members and trustees of the Institute believe that questions regarding health and safety are best resolved when scientists can ex amine and discuss issues, as an independent body, se~arate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refinement of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have largely been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results. Publicity surrounding toxicologic issues has created chronic public apprehension about the ability of science and government to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government and industry, with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.

Keywords

kinetics metabolism mutagen pharmacokinetics research toxicity toxicology

Editors and affiliations

  • H. C. Grice
    • 1
  1. 1.NepeanCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-49371-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1984
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-13696-5
  • Online ISBN 978-3-642-49371-3
  • Series Print ISSN 1431-2468
  • Buy this book on publisher's site