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Platinum Coordination Complexes in Cancer Chemotherapy

  • T. A. Connors
  • J. J. Roberts

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 48)

Table of contents

  1. Front Matter
    Pages I-XII
  2. Chemistry

  3. Interaction with Biomacromolecules

  4. Bacterial, Viral and Tissue Culture Studies

  5. Animals Studies

  6. Clinical Trials

  7. Back Matter
    Pages 197-202

About this book

Introduction

It was a great pleasure and honour to have been invited to attend this Seminar and to present a final impression. The association in this field between the Chester Beatty Research Institute and Dr. Rosenberg's School at East Lansing is something which I specially value and many would doubtless like to know how it came about. In the course of its work in carcinogenesis and on chemotherapy over many years, the Chester Beatty Research Institute was frequently drawn to the importance of many metals - as for example lead, iron, metalloid arsenic and the metalloid quali­ ties of the carcinogenic hydrocarbons. Interest started in platinum many years ago, following the possibility, c1aimed by others, that various complexes between the metal and mercaptopurine might possess significant chemotherapeutic properties. Va­ rious attempts to confirm such findings ended, however, in complete failure. Interest in platinum was revived by the fresh observations of Dr. Rosenberg and his collea­ gues, and here the outcome was entirely different. Very soon it was possible to con­ firm the intense growth-inhibitory properties of cis-platinum (II) diamminedi­ chloride and related substances. After communicating these results to Dr. Rosenberg, it was a pleasure to welcome hirn in London where he gave a Seminar which greatly engaged the interest of many of the staff. Later, several of these were to enjoy Dr. Rosenberg's hospitality at an international conference on the subject to be held in East Lansing, where many rapidly developing aspects were open for discussion.

Keywords

Platinum cancer carcinogenesis growth hospital therapy

Editors and affiliations

  • T. A. Connors
    • 1
  • J. J. Roberts
    • 2
  1. 1.Chester Beatty Research Institute, Institute of Cancer ResearchRoyal Cancer HospitalLondonUK
  2. 2.Chester Beatty Research Institute, Institute of Cancer ResearchRoyal Cancer HospitalLondonUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-49306-5
  • Copyright Information Springer-Verlag Berlin Heidelberg 1974
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-49308-9
  • Online ISBN 978-3-642-49306-5
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site