Statistical Methods in Toxicology

Proceedings of a Workshop during EUROTOX ’90 Leipzig, Germany, September 12–14, 1990

  • Ludwig Hothorn

Part of the Lecture Notes in Medical Informatics book series (LNMED, volume 43)

Table of contents

  1. Front Matter
    Pages N2-IV
  2. Introduction

  3. Biostatistical Analysis of mutagenicity assays

    1. Martin Schumacher, Claudia Schmoor
      Pages 5-19
    2. Stefan Rettig, Jürgen Lehn, Herbert G. Miltenburger
      Pages 25-34
    3. Walter W. Piegorsch, Errol Zeiger
      Pages 35-41
  4. Biostatistical analysis of long-term carcinogenicity studies

  5. Biostatistical analysis of embryo-toxicity studies

    1. Walter W. Piegorsch, Joseph K. Haseman
      Pages 86-95
    2. Reinhard Meister, Ibrahim Chahoud, Maike Jürgens, Frank Iversen, Gerd Bochert
      Pages 96-103
  6. General principles in biostatidtical analysis of toxicological Studies

  7. Back Matter
    Pages 157-161

About these proceedings


This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.


ANOVA Generalized linear model Statistik Toxikologie evaluation mutagen research statistics toxicity toxicology

Editors and affiliations

  • Ludwig Hothorn
    • 1
  1. 1.Institute of Epidemiology and BiometryGerman Cancer Research Center HeidelbergHeidelbergGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-53621-5
  • Online ISBN 978-3-642-48736-1
  • Series Print ISSN 0172-7788
  • Buy this book on publisher's site