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Specificity, Function, and Development of NK Cells

NK Cells: The Effector Arm of Innate Immunity

  • Klas Kärre
  • Marco Colonna

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 230)

Table of contents

  1. Front Matter
    Pages I-IX
  2. NK Receptors and Coreceptors

    1. Front Matter
      Pages 1-1
    2. A. Moretta, S. Sivori, M. Ponte, M. C. Mingari, L. Moretta
      Pages 15-23
    3. A. D’Andrea, L. L. Lanier
      Pages 25-39
    4. M. López-Botet, M. Carretero, T. Bellón, J. J. Pérez-Villar, M. Llano, F. Navarro
      Pages 41-52
    5. B. J. Chambers, J. L. Wilson, M. Salcedo, K. Markovic, M. T. Bejarano, H. G. Ljunggren
      Pages 53-61
    6. B. Perussia
      Pages 63-88
    7. T. S. Helander, T. Timonen
      Pages 89-99
  3. Activation of NK Cells and Effector Functions

    1. Front Matter
      Pages 101-101
    2. K. M. Brumbaugh, B. A. Binstadt, P. J. Leibson
      Pages 103-122
    3. M. F. Van den Broek, D. Kägi, H. Hengartner
      Pages 123-131
  4. Development of NK Cells

    1. Front Matter
      Pages 133-133
    2. P. V. Sivakumar, I. Puzanov, N. S. Williams, M. Bennett, V. Kumar
      Pages 161-190
  5. Role of NK Cells in Infections and Tumors

    1. Front Matter
      Pages 191-191
    2. C. H. Tay, E. Szomolanyi-Tsuda, R. M. Welsh
      Pages 193-220
    3. T. L. Whiteside, N. L. Vujanovic, R. B. Herberman
      Pages 221-244
  6. Back Matter
    Pages 245-250

About this book

Introduction

Our understanding of the function of natural killer (NK) cells has dramatically changed in recent years. The discovery of NK receptors specific for MHC class I molecules, and the study of the role of co-stimulatory and adhesion molecules have led to an understanding of how NK cells recognize tumor and virally infected cells that have lost expression of MHC class I molecules or have altered distribution of normal cell surface molecules. Such recognition events lead to intracellular signals which can be either stimulatory or inhibitory. This book provides an insight into how NK cells develop, how they learn to distinguish altered cells from normal cells, and into their biological role in controlling infections and tumors.

Keywords

Infektion Krebs Krebstherapie MHC NK cells cancer cancer therapy cell cytotoxicity infection inhibitory receptors natural killer cells polymorphism tumor tumor therapy

Editors and affiliations

  • Klas Kärre
    • 1
  • Marco Colonna
    • 2
  1. 1.Karolinska InstituteMicrobiology and Tumor Biology CenterStockholmSweden
  2. 2.Basel Institute for ImmunologyBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-46859-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1998
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-46861-2
  • Online ISBN 978-3-642-46859-9
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site