Mechanism of Action of Antieukaryotic and Antiviral Compounds

  • Fred E. Hahn

Part of the Antibiotics book series (ANTIBIOTICS, volume 5 / 2)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. A. Jiménez, D. Vázquez
    Pages 1-19
  3. J. J. Roberts
    Pages 20-84
  4. C. E. Cass
    Pages 85-109
  5. D. Grunberger, G. Grunberger
    Pages 110-123
  6. C. W. Haidle, R. S. Lloyd
    Pages 124-154
  7. K. W. Kohn, W. E. Ross, D. Glaubiger
    Pages 195-213
  8. J. G. Olenick
    Pages 214-222
  9. B. Festy
    Pages 223-235
  10. W. H. Prusoff, M. S. Chen, P. H. Fischer, T. S. Lin, G. T. Shiau
    Pages 236-261
  11. I. H. Goldberg
    Pages 262-274
  12. M. Gniazdowski, J. Filipski, M. Chorąży
    Pages 275-297
  13. Ch. F. Earhart Jr.
    Pages 298-312
  14. F. E. Hahn
    Pages 353-362
  15. D. W. Visser, S. Roy-Burman
    Pages 363-371
  16. N. S. Mizuno
    Pages 372-384
  17. P. Chandra, M. Woltersdorf, G. J. Wright
    Pages 385-413
  18. W. A. Creasey
    Pages 414-438
  19. F. E. Hahn
    Pages 439-458
  20. Back Matter
    Pages 459-472

About this book


When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan­ isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto­ myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti­ cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti­ microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.


Antibiotikum Antimykotikum Chemotherapeutikum Virostatikum alkaloids antibiotic antibiotics cancer environment research

Editors and affiliations

  • Fred E. Hahn
    • 1
  1. 1.Department of the Army, Walter Reed Army Institute of ResearchWalter Reed Army Medical CenterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin · Heidelberg 1979
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-46409-6
  • Online ISBN 978-3-642-46407-2
  • Buy this book on publisher's site