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Concepts in Biochemical Pharmacology

Part 3

  • James R. Gillette
  • Jerry R. Mitchell

Table of contents

  1. Front Matter
    Pages II-XXVIII
  2. Determinants of Drug Concentration and Activity

    1. G. Levy, M. Gibaldi
      Pages 1-34
    2. J. R. Gillette
      Pages 35-85
    3. G. A. Digenis, J. V. Swintosky
      Pages 86-112
    4. S. Garattini, F. Marcucci, E. Mussini
      Pages 113-129
    5. G. L. Plaa
      Pages 130-149
    6. C. T. Dollery, D. S. Davies
      Pages 150-168
    7. W. W. Weber, S. N. Cohen
      Pages 213-233
  3. Drug Interactions and Adverse Drug Reactions

    1. D. G. Shand, J. R. Mitchell, J. A. Oates
      Pages 272-314
    2. B. A. Chabner, V. T. Oliverio
      Pages 325-342
    3. E. Jawetz
      Pages 343-358
  4. Perspectives on the Importance of Drug Disposition in Drug Therapy and Toxicology

    1. J. R. Gillette, J. R. Mitchell
      Pages 359-382
    2. J. R. Mitchell, W. Z. Potter, J. A. Hinson, W. R. Snodgrass, J. A. Timbrell, J. R. Gillette
      Pages 383-419
  5. Back Matter
    Pages 420-482

About this book

Introduction

Part 3 of the Handbook of Experimental Pharmacology (Concepts in Biochem­ ical Pharmacology) applies the principles enunciated in Parts 1 and 2 to clinical pharmacology and toxicology. The major objective is to elucidate the many factors that determine the relationships between pharmacokinetic aspects of the disposition and metabolism of drugs and their therapeutic or toxic actions in man. Because of the more restricted information obtainable in human studies, this volume reflects the editors' bias that an understanding of pharmacokinetics is fundamental for assessing pharmacologic or toxicologic effects of drugs in humans. The first chapter is a unique primer on when to apply and how to use pharmaco­ kinetic tools in human pharmacology. The second chapter explains the general assumptions underlying pharmacokinetic approaches both in simple terms for the novice and in mathematical form for the more sophisticated reader. Several chapters on determinants of drug concentration and activity discuss drug absorption, drug latentiation, drugs acting through metabolites, entero­ hepatic drug circulation, influence of route of drug administration on response, genetic variations in drug disposition and response, age differences in absorption, distribution and excretion of drugs, and pathologic and physiologic factors affecting absorption, distribution and excretion of drugs and drug response. The focus of these chapters is data obtained in human, rather than animal, studies. Most of the chapters contain new material never summarized previously.

Keywords

absorption drug kinetics metabolism pharmacokinetics pharmacology research toxicology

Editors and affiliations

  • James R. Gillette
    • 1
  • Jerry R. Mitchell
    • 1
  1. 1.Laboratory of Chemical Pharmacology, National Heart and Lung InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-46314-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1975
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-46316-7
  • Online ISBN 978-3-642-46314-3
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site