Malignant Tumors in Organ Transplant Recipients

  • Israel Penn

Table of contents

  1. Front Matter
    Pages i-xi
  2. Israel Penn
    Pages 1-1
  3. Israel Penn
    Pages 9-35
  4. Israel Penn
    Pages 40-40
  5. Back Matter
    Pages 40-55

About this book

Introduction

There is a great deal of experimental work leading to the conclusion that immuno­ suppression of any kind increases susceptibility to clinical or viral carcinogenesis. Human epidemiology had already given some intimation of the abnormally high incidence of neoplasms in persons suffering from immunologic insufficiency. The first statistics on the incidence of cancer in organ transplant recipients tend to support this thesis. Transplantation can favor metastasis in a recipient who already has a malignancy; similarly, it can encourage the development of tumor cells which may be present in an organ transplanted from a cancerous donor; and finally, the frequency of lymphomas and carcinomas is higher in transplant recipients than in the general population. Immunodepression induced to facilitate tolerance clearly falls under suspicion on the basis of the experimental and clinical findings mentioned above. Anti-lymphocyte serum is not the only suspect-tumors have also occurred in patients treated with prednisone and Imuran alone. Now comes Dr. PENN'S monograph with a detailed account of these phenomena, together with an analysis and discussion. Clearly, induced carcinogenesis in man must be taken seriously. Not only must every precaution be taken in the screening of donor and recipient and the choice of immunosuppressive therapy in order to reduce it to the minimum, there is also the question whether the long-term immunosuppressive treatments inflicted upon patients in whom an auto-immune mechanism is thought to be the cause of the disease-treat­ ments whose efficacy is even more questionable than the mechanism-might not themselves be contributing to malignancy.

Keywords

Organ Tumors cancer carcinogenesis carcinoma lymphoma metastasis neoplasm screening therapy transplantation tumor

Authors and affiliations

  • Israel Penn
    • 1
    • 2
    • 3
  1. 1.University of Colorado Medical CenterUSA
  2. 2.Veterans Administration HospitalDenverUSA
  3. 3.Colorado General HospitalUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-46255-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1970
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-46257-3
  • Online ISBN 978-3-642-46255-9
  • Series Print ISSN 0080-0015
  • About this book