Mechanism of Action

1. Gougerotin

   • John M. Clark Jr.

   Pages 278-282

2. Cycloheximide and Other Glutarimide Antibiotics

   • Hugh D. Sisler, Malcolm R. Siegel

   Pages 283-307

3. Chloramphenicol

   • F. E. Hahn

   Pages 308-330

4. Tetracyclines

   • Allen I. Laskin

   Pages 331-359

5. Tenuazonic Acid

   • Harold T. Shigeura

   Pages 360-365

6. Macrolide antibiotics — Spiramycin, Carbomycin, Angolamycin, Methymycin and Lancamycin

   • D. Vazquez

   Pages 366-377

7. Erythromycin and Oleandomycin

   • F. E. Hahn

   Pages 378-386

8. The Streptogramin Family of Antibiotics

   • D. Vazquez

   Pages 387-403

9. Fucidin

   • C. L. Harvey, C. J. Sih, S. G. Knight

   Pages 404-409

10. Sparsomycin

    • Libor Slechta

    Pages 410-414

11. Rifamycins

    • Laura Frontali, Giorgio Tecce

    Pages 415-426

12. Nucleocidin

    • J. R. Florini

    Pages 427-433

13. Blasticidin S

    • Tomomasa Misato

    Pages 434-439

14. Lincomycin

    • F. N. Chang, B. Weisblum

    Pages 440-445

15. Chalcomycin

    • D. C. Jordan

    Pages 446-450

16. Hadacidin

    • Harold T. Shigeura

    Pages 451-456

17. Psicofuranine

    • Ladislav J. Hanka

    Pages 457-463

18. Angustmycin A

    • Armand J. Guarino

    Pages 464-467

19. Cordycepin

    • Armand J. Guarino

    Pages 468-480

20. Azaserine and 6-Diazo-5-Oxo-L-Norleucine (DON)

    • R. F. Pittillo, D. E. Hunt

    Pages 481-493

The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a biblio­ graphy on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving for­ ward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entity with a life of its own, that we were letting loose a Golom who instead of being our servant would be our master. That we set up ideals for these books is obvious; they would be current guides to developments and information in the areas of mechanism of action and bio­ synthesis of antibiotics. For almost every subject, we wished to enlist the aid of an investigator who himself had played a part in determining the nature of the phenomena that were being discussed. One concept for the books was that they include only antibiotics for which a definitive, well-documented mechanism of action or biosynthetic pathway was known.

• Chloramphenicol
• Tetracycline
• antibiotics
• bacteria
• biology
• biosynthesis
• cell
• chemistry
• microbiology
• protein

• University of Illinois, Urbana, USA

  David Gottlieb, Paul D. Shaw

Policies and ethics