Cell Kinetic Modelling and the Chemotherapy of Cancer

  • Helmut Knolle

Part of the Lecture Notes in Biomathematics book series (LNBM, volume 75)

Table of contents

  1. Front Matter
    Pages N2-VIII
  2. Helmut Knolle
    Pages 1-45
  3. Helmut Knolle
    Pages 46-83
  4. Helmut Knolle
    Pages 84-131
  5. Back Matter
    Pages 132-161

About this book


During the last 30 years, many chemical compounds that are active against tumors have been discovered or developed. At the same time, new methods of testing drugs for cancer therapy have evolved. nefore 1964, drug testing on animal tumors was directed to observation of the incfease in life span of the host after a single dose. A new approach, in which the effects of multiple doses on the proliferation kinetics of the tumor in vivo as well as of cell lines in vitro are investigated, has been outlined by Skipper and his co-workers in a series of papers beginning in 1964 (Skipper, Schabel and Wilcox, 1964 and 1965). They also investigated the influence of the time schedule in the treatment of experimental tumors. Since the publication of those studies, cell population kinetics cannot be left out of any discussion of the rational basis of chemotherapy. When clinical oncologists began to apply cell kinetic concepts in practice about 15 years ago, the theoretical basis was still very poor, in spite of Skipper's progress, and the lack of re­ levant cytokinetic and pharmacologic data was apparent. Subsequently, much theoretical work has been done and many cell kinetic models have been elaborated (for a review see Eisen, 1977).


algebra cancer cancer research cell cell cycle kinetics tumor tumor growth

Authors and affiliations

  • Helmut Knolle
    • 1
  1. 1.Abteilung für Epidemiologie und SozialmedizinMedizinische Hochschule HannoverHannover 61Federal Republic of Germany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1988
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-540-50153-4
  • Online ISBN 978-3-642-45651-0
  • Series Print ISSN 0341-633X
  • Buy this book on publisher's site