Treatment–Refractory Schizophrenia

A Clinical Conundrum

  • Peter F. Buckley
  • Fiona Gaughran

Table of contents

  1. Front Matter
    Pages i-viii
  2. Derek K. Tracy, Sukhwinder S. Shergill
    Pages 1-19
  3. Arsime Demjaha, Oliver D. Howes
    Pages 31-43
  4. Siobhan Gee, David Taylor
    Pages 65-80
  5. Peter B. Rosenquist, Anthony O. Ahmed, W. Vaughn McCall
    Pages 107-120
  6. Andrew Watson, Matteo Cella, Til Wykes
    Pages 121-137
  7. Elaine C. M. Hunter, Louise C. Johns, Juliana Onwumere, Emmanuelle Peters
    Pages 139-164
  8. Susan R. McGurk, Kim T. Mueser
    Pages 165-177
  9. Adriana Foster, Peter F. Buckley
    Pages 179-193
  10. Juliana Onwumere, Elaine Hunter, Elizabeth Kuipers
    Pages 195-223
  11. Back Matter
    Pages 225-230

About this book


Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population  - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care.


In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused  book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.


Antipsychotic medications Biology of schizophrenia Chronic schizophrenia Clozapine therapy Pharmacologic treatments for Schizophrenia Phychological therapy in Schizophrenia Treatment Refractory Schizophrenia Treatment Resistant Schizophrenia

Editors and affiliations

  • Peter F. Buckley
    • 1
  • Fiona Gaughran
    • 2
  1. 1.Medical College of Georgia Dean’s OfficeGeorgia Regents UniversityAugustaUSA
  2. 2.Department of Psychosis StudiesInstitute of Psychiatry, National Psychosis UnitLondonUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-45256-7
  • Online ISBN 978-3-642-45257-4
  • Buy this book on publisher's site