Antimicrobials

New and Old Molecules in the Fight Against Multi-resistant Bacteria

  • Flavia Marinelli
  • Olga Genilloud

Table of contents

  1. Front Matter
    Pages i-viii
  2. Current Trends in Antibiotics, Pathogens and Medical Needs

  3. Families of Novel Candidates and Conventional Antibiotics

    1. Front Matter
      Pages 57-57
    2. Erika Leemans, Jed F. Fisher, Shahriar Mobashery
      Pages 59-84
    3. Giorgia Letizia Marcone, Flavia Marinelli
      Pages 85-107
    4. Herbert A. Kirst, Flavia Marinelli
      Pages 193-209
    5. Herbert A. Kirst
      Pages 211-230
    6. Olga Genilloud, Francisca Vicente
      Pages 231-245
    7. Giovanni Zappia, Cinzia Ingallina, Francesca Ghirga, Bruno Botta
      Pages 247-266
    8. Michael J. Pucci, Jason A. Wiles
      Pages 307-326

About this book

Introduction

Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens.

This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.

Keywords

Antibiotics Bioactive molecules Drug resistance Infectious diseases

Editors and affiliations

  • Flavia Marinelli
    • 1
  • Olga Genilloud
    • 2
  1. 1.Dipartimento di Biotecnologie e Scienze MolecolariUniversità degli Studi dell'InsubriaVareseItaly
  2. 2.Parque Tecnológico Ciencias de la SaludFundación MEDINAGranadaSpain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-39968-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-642-39967-1
  • Online ISBN 978-3-642-39968-8
  • About this book