Nucleic Acid Polymerases

  • Katsuhiko S. Murakami
  • Michael A. Trakselis

Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 30)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Michael A. Trakselis, Katsuhiko S. Murakami
    Pages 1-15
  3. Erin Walsh, Kristin A. Eckert
    Pages 17-41
  4. Robert W. Sobol
    Pages 43-83
  5. John M. Pryor, Lynne M. Dieckman, Elizabeth M. Boehm, M. Todd Washington
    Pages 85-108
  6. Roberto Laos, Ryan W. Shaw, Steven A. Benner
    Pages 163-187
  7. Stuart F. J. Le Grice, Marcin Nowotny
    Pages 189-214
  8. Andrew F. Brown, Joshua D. Podlevsky, Julian J.-L. Chen
    Pages 215-235
  9. Ritwika S. Basu, Katsuhiko S. Murakami
    Pages 237-250
  10. Y. Whitney Yin
    Pages 251-275
  11. David A. Bushnell, Roger D. Kornberg
    Pages 277-287
  12. Thomas S. Ream, Jeremy R. Haag, Craig S. Pikaard
    Pages 289-308
  13. David D. Boehr, Jamie J. Arnold, Ibrahim M. Moustafa, Craig E. Cameron
    Pages 309-333
  14. Back Matter
    Pages 335-342

About this book


This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans.

Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.


DNA replication Gene Expression Nucleic Acids Polymerase RNA transcription

Editors and affiliations

  • Katsuhiko S. Murakami
    • 1
  • Michael A. Trakselis
    • 2
  1. 1.Dept. of Biochem. and Mol. BiologyThe Pennsylvania State UniversityUniversity ParkUSA
  2. 2.Department of ChemistryUniversity of PittsburghPittsburghUSA

Bibliographic information